Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]
, 2017 Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina +3 more
core +1 more source
Mammalian DNA cytosine‐5 methyltransferase interacts with p23 protein [PDF]
FEBS Letters, 1996 In higher eukaryotic genomes, methylated cytosine residues (m5C) are distributed in heritable, cell‐type‐specific patterns, which are believed to be involved in the control of gene expression, developmental regulation and genomic imprinting. These methylation patterns are established and maintained by DNA cytosine‐5 methyltransferase (MTase), a ∼1500 ...
Zhang, Xiaoyan, Verdine, Gregory L.
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Investigations into the molecular effects of single nucleotide polymorphism [PDF]
, 2000 Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe
core +1 more source
Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins [PDF]
, 2003 A method to detect DNA-binding sites on the surface of a protein structure is important for functional annotation. This work describes the analysis of residue patches on the surface of DNA-binding proteins and the development of a method of predicting ...
Berman, Helen M +3 more
core +4 more sources
DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Kuo, YY, Li, LY, Tien, HF
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{BiQ} Analyzer {HiMod}: An Interactive Software Tool for High-throughput Locus-specific Analysis of 5-Methylcytosine and its Oxidized Derivatives [PDF]
, 2014 Recent data suggest important biological roles for oxidative modifications of methylated cytosines, specifically hydroxymethylation, formylation and carboxylation. Several assays are now available for profiling these DNA modifications genome-wide as well
Becker, D. +5 more
core +2 more sources
PLoS ONE, 2013 5-methylcytosine (5-mC) can be sequentially oxidized to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-foC), and finally to 5-carboxylcytosine (5-caC), which is thought to function in active DNA cytosine demethylation in mammals. Although the roles
Xi-Wen Xing +6 more
doaj +1 more source
Repeats as global DNA methylation marker in bovine preimplantation embryos [PDF]
, 2017 DNA methylation undergoes dynamic changes and is a crucial part of the epigenetic regulation during mammalian early development. To determine the DNA methylation levels in bovine embryos, we applied a bisulfite sequencing based method aimed at repetitive
Li, Wenwen, Peelman, Luc, Van Soom, Ann
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Changes in liver cell DNA methylation status in diabetic mice affect its FT-IR characteristics. [PDF]
PLoS ONE, 2014 Lower levels of cytosine methylation have been found in the liver cell DNA from non-obese diabetic (NOD) mice under hyperglycemic conditions. Because the Fourier transform-infrared (FT-IR) profiles of dry DNA samples are differently affected by DNA base ...
Benedicto de Campos Vidal +2 more
doaj +1 more source
DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta), with data on DNA, on the protein encoded, and where the gene is implicated.
Ben, Gacem R +3 more
openaire +2 more sources