Results 31 to 40 of about 108,714 (328)
Base Flip in DNA Studied by Molecular Dynamics Simulations of Differently-Oxidized Forms of Methyl-Cytosine [PDF]
, 2014 : Distortions in the DNA sequence, such as damage or mispairs, are specifically recognized and processed by DNA repair enzymes. Many repair proteins and, in particular, glycosylases flip the target base out of the DNA helix into the enzyme’s active site.
Helabad, Mahdi Bagherpoor +2 more
core +3 more sources
Epigenetics & Chromatin, 2018 Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao +5 more
doaj +1 more source
Intramolecular folding in human ILPR fragment with three C-rich repeats. [PDF]
PLoS ONE, 2012 Enrichment of four tandem repeats of guanine (G) rich and cytosine (C) rich sequences in functionally important regions of human genome forebodes the biological implications of four-stranded DNA structures, such as G-quadruplex and i-motif, that can form
Soma Dhakal +4 more
doaj +1 more source
Bypass of a protein roadblock by a replicative DNA helicase [PDF]
, 2014 Replicative DNA helicases generally unwind DNA as a single hexamer that encircles and translocates along one strand of the duplex while excluding the complementary strand (“steric exclusion”).
Hurwitz, Jerard +7 more
core +1 more source
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome [PDF]
, 2019 DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability.
Allison, Rachal M +5 more
core +1 more source
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Frontiers in Genetics, 2018 Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants. Though much attention is given to the conventional epigenetic signature 5-methylcytosine (5-mC), the field of epigenetics is attracting ...
Suresh Kumar +2 more
doaj +1 more source
Nature Communications, 2020 Circulating DNA detected in plasma can be used for diagnostic purposes. Here, the authors show that the 5-hydroxymethyl cytosine biomarker from plasma-derived cell free DNA can be used to detect early stage pancreatic cancer.
Gulfem D. Guler +15 more
doaj +1 more source
An orphan DNA (cytosine-5-)-methyltransferase in Vibrio cholerae [PDF]
Microbiology, 2006 5-Methyl cytosine (m5C) was detected in genomic DNA of the enteric pathogen Vibrio cholerae by HPLC analysis and immunoblotting with m5C-specific antibody. Although cleavage with the restriction endonuclease EcoRII revealed the absence of a Dcm homologue in V.
Sanjib, Banerjee, Rukhsana, Chowdhury
openaire +2 more sources
5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development [PDF]
, 2012 5-hydroxymethyl-cytosine (5-hmc) is a cytosine modification that is relatively abundant in mammalian pre-implantation embryos and embryonic stem cells (Esc) derived from mammalian blastocysts.
Alexey Ruzov +41 more
core +2 more sources
Fluorescent Method for the Detection of Biothiols Using an Ag+-Mediated Conformational Switch
Sensors, 2019 In this work, a novel, simple, and time-saving fluorescence approach for the detection of biothiols (glutathione and cysteine) was developed by employing a DNA probe labeled with 2-aminopurine.
Han Zhao, Mingjian Chen, Changbei Ma
doaj +1 more source