Results 261 to 270 of about 1,846,477 (392)

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses [PDF]

, 2017
Tanggang Deng, Guobei Yan, Yu Zhou, Xiaoxiao Hu, Jianglin Li, Jun Hu, Hui Zhang, Peifu Feng, Xunan Sheng, Jieying Chen, Hongchang Ma, Yang Sun, Wei Dong, Bin Hu, Jing Liu, Weihong Tan, Mao Ye   +16 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Chromatin relaxation dynamics and histone PTMs in the early DNA damage response. [PDF]

Cancer Biol Med
Qian J, Xie Z, Zhou L, Zhu WG.
europepmc   +1 more source

APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression

, 2020
Hiroyuki Yamazaki, Kotaro Shirakawa, Tadahiko Matsumoto, Yasuhiro Kazuma, Hiroyuki Matsui, Yoshihito Horisawa, Emani Stanford, Anamaria Daniela Sarca, Ryutaro Shirakawa, Keisuke Shindo, Akifumi Takaori‐Kondo   +10 more
openalex   +2 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Targeting DNA Damage Response and Immune Crosstalk in Cancer: Mechanistic Insights and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Marcut L, Brata RD, Barb AC, Manole A, Stef DG, Dumitru CS, Zara F, Patrascu R.   +7 more
europepmc   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease. [PDF]

EMBO J
Sepe S, Rey F, Mancheno-Ferris A, Bigi A, Fani G, Damiani D, Cabrini M, Marinelli E, Aguado J, Contu L, di Lillo A, Boggio S, Tavella S, Rosso I, Gustincich S, Chiti F, d'Adda di Fagagna F.   +16 more
europepmc   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Expression of miRNAs Associated With Embryo Development and DNA Damage Response in Porcine Embryos. [PDF]

Mol Reprod Dev
Pineda G, Facioli FL, Macedo MP, Guay V, Currin L, Gutierrez K, Bordignon V, Glanzner WG.   +7 more
europepmc   +1 more source