Results 271 to 280 of about 1,846,477 (392)

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

IFI16 Enhances Chemosensitivity of Breast Cancer Cells by Inhibiting DNA Damage Response. [PDF]

Biomol Ther (Seoul)
Ka NL, Lim GY, Kim SS, Lee MO.
europepmc   +1 more source

LIM Protein Ajuba Directly Interacts with Replication Protein A to Prevent ATR DNA Damage Response

, 2017
Sandy Fowler
openalex   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Histone PARylation factor 1: a review of its role in the DNA damage response. [PDF]

Nucleic Acids Res
Rudolph J, Luger K.
europepmc   +1 more source

Uncovering senescent fibroblast heterogeneity connects DNA damage response to idiopathic pulmonary fibrosis

Jun‐Wei B. Hughes, Akshay Pujari, Anja Sandholm, Duncan Croll, Lea B. Monk, Isaac Joshua, Russell J. Butterfield, W. Horton, Kevin Schneider, Fiona Senchyna, Ian R. Brown, Ana Lúcia Coelho, T. Ho, Hideto Deguchi, Claude Jourdan Le Saux, Stefanie Deinhardt‐Emmer, Lisa Ellerby, Alberto Vitari, David Furman, Cory M. Hogoboam, Alexander M Laslavic, Pierre‐Yves Desprez, Marco Quarta, Judith Campisi   +23 more
openalex   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Cellular metabolic response to DNA damage

BMC Proceedings, 2012
Haigis Marcia C, Jeong Seung
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression. [PDF]

FEBS Lett
Redeker H, Kebel S, Völkening L, Vatselia A, Weinhold L, Asgedom G, Schambach A, Schindler D, Dörk T, Bousset K.   +9 more
europepmc   +1 more source