Results 111 to 120 of about 2,011,431 (260)

Overexpression of AtOGG1, a DNA glycosylase/AP lyase, enhances seed longevity and abiotic stress tolerance in Arabidopsis.

Journal of Experimental Botany, 2012
Reactive oxygen species (ROS) are toxic by-products generated continuously during seed desiccation, storage, and germination, resulting in seed deterioration and therefore decreased seed longevity.
Huhui Chen, Pu Chu, Yuliang Zhou, Yin Li, Jun Liu, Yu Ding, E. Tsang, Liwen Jiang, Keqiang Wu, Shangzhi Huang   +9 more
semanticscholar   +1 more source

Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ/− Mice

Aging Cell, EarlyView.
Dietary restriction mitigates vascular aging in DNA‐repair‐deficient Ercc1Δ/− mice by reducing extracellular matrix remodeling, inflammation, oxidative stress, and switching of vascular smooth muscle cells to a macrophage‐like phenotype. Our findings suggest that the cGAS‐STING pathway plays a key role in vascular aging and that the benefits of dietary
S. J. M. Stefens, J. van der Linden, J. M. Heredia‐Genestar, R. M. C. Brandt, S. Barnhoorn, I. Nieuwenhuizen‐Bakker, N. van Vliet, J. H. M. Odijk, Y. Ridwan, D. Stuijts, M. Batenburg, J. H. J. Hoeijmakers, R. Kanaar, J. Essers, I. van der Pluijm   +14 more
wiley   +1 more source

Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase [PDF]

, 1978
Bruce K. Duncan, P A Rockstroh, Huber R. Warner   +2 more
openalex   +1 more source

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

Nucleic Acids Research, 2012
The mammalian DNA glycosylase—methyl-CpG binding domain protein 4 (MBD4)—is involved in active DNA demethylation via the base excision repair pathway. MBD4 contains an N-terminal MBD and a C-terminal DNA glycosylase domain. MBD4 can excise the mismatched
H. Hashimoto, Xing Zhang, Xiaodong Cheng
semanticscholar   +1 more source

Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system

Cancer Management and Research, 2019
Fubiao Ni,1,* Hengjie Tang,1,* Cheng Wang,1,* Zixiang Wang,2 Fangyi Yu,2 Bicheng Chen,1 Linxiao Sun1 1Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery ...
Ni F, Tang H, Wang C, Wang Z, Yu F, Chen B, Sun L   +6 more
doaj  

DNA Linear Block Codes: Generation, Error-detection and Error-correction of DNA Codeword [PDF]

International Journal of Bioinformatics Intelligent Computing. 2022;1(2):103-126, 2019
In modern age, the increasing complexity of computation and communication technology is leading us towards the necessity of new paradigm. As a result, unconventional approach like DNA coding theory is gaining considerable attention. The storage capacity, information processing and transmission properties of DNA molecules stimulate the notion of DNA ...
arxiv  

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung−/−Msh2−/− mice

Nucleic Acids Research, 2012
Deamination of cytosine (C), 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) occurs spontaneously in mammalian DNA with several hundred deaminations occurring in each cell every day.
K. Kemmerich, Felix A. Dingler, C. Rada, M. Neuberger   +3 more
semanticscholar   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Uracil DNA-glycosylase from HeLa cells: general properties, substrate specificity and effect of uracil analogs [PDF]

, 1981
Hans E. Krokan, Christian Urs Wittwer
openalex   +1 more source