Results 221 to 230 of about 2,102,008 (248)

Condensin complexes: from chromatin organization to disease. [PDF]

Nucleus
Shu L, Zhang H.
europepmc   +1 more source

Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling. [PDF]

Adv Sci (Weinh)
Tang J, Feng C, Su H, Chu X.
europepmc   +1 more source

Structural and mechanistic perspectives on Nse5/6 regulation of the Smc5/6 complex. [PDF]

Front Mol Biosci
Kim JH, Rao DR, Kim KD.
europepmc   +1 more source

TF-loop: deciphering the transcription factor regulatory language for CTCF-mediated chromatin loop based on BERT. [PDF]

Brief Bioinform
Qi YX, Zhang HJ, Tang HX, Zhang ZX, Han KY, Zhang Z, Ding H, Liu L, Wang YY.   +8 more
europepmc   +1 more source

Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA. [PDF]

Nucleic Acids Res
Conforto F, Valdes A, Vanderlinden W, Michieletto D.   +3 more
europepmc   +1 more source

Self-organization of Drosophila chromatin architecture in a cell-free system

Jayakrishnan M, Kars G, Campos-Sparr A, Karpinska MA, Zunjarrao S, Maziak N, Margulies CE, Vaquerizas JM, Gambetta MC, Oudelaar AM, Becker PB.   +10 more
europepmc   +1 more source

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A hold-and-feed mechanism drives directional DNA loop extrusion by condensin

Science, 2022
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by extruding DNA loops, but the molecular mechanism that underlies their activity has remained unknown. We show that the active condensin complex entraps the bases of a DNA loop transiently in two separate chambers.
Christian Haering, Maria Sol Bravo, Sumanjit Datta   +2 more
exaly   +3 more sources

Transcription and topoisomerases bring new twists to DNA loop extrusion by cohesin

Molecular Cell, 2021
Neguembor et al. (2021) use super-resolution microscopy to illuminate genome packaging inside the cell nucleus. They discover that transcription and topoisomerases protect chromatin from collapsing in a crumpled state refractory to DNA loop extrusion by cohesin proteins.
Rini, Shah, Elphège P, Nora
openaire   +2 more sources

DNA capture and loop extrusion dynamics by cohesin-NIPBL

2022
ABSTRACT 3D chromatin organization plays a critical role in regulating gene expression, DNA replication, recombination, and repair. While initially discovered for its role in sister chromatid cohesion, emerging evidence suggests that the cohesin complex (SMC1, SMC3, RAD21, and SA1/SA2), facilitated by NIPBL, mediates topologically ...
Parminder Kaur, Zhubing Shi, Xiaotong Lu, Hongshan Zhang, Ilya J. Finkelstein, Yizhi Jane Tao, Hongtao Yu, Hong Wang   +7 more
openaire   +1 more source

Live imaging of DNA loop extrusion

Science, 2018
Molecular Biology To spatially organize chromosomes, ring-shaped protein complexes including condensin and cohesin have been hypothesized to extrude DNA loops. Condensin has been shown to exhibit a DNA-translocating motor function, but extrusion has not been observed directly.
openaire   +1 more source