DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities. [PDF]
Clin EpigeneticsAbnormal DNA methylation is a hallmark of cancer and a nearly universal feature of melanoma. DNA methylation plays well-appreciated melanoma cell-intrinsic roles, including silencing tumor-suppressor genes, regulating genomic stability, deregulating ...
Deshmukh MG +5 more
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SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers. [PDF]
Nat CommunDNA methylation is an epigenetic mark that plays a critical role in regulating gene expression. DNA methyltransferase (DNMT) inhibitors, inhibit global DNA methylation and have been a key tool in studies of DNA methylation. A major bottleneck is the lack
Hosseinpour M +13 more
europepmc +2 more sources
Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing [PDF]
Journal of Epigenetics, 2022 Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection.
Samina Gul, Tang Wenru
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Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. [PDF]
PLoS ONE, 2011 DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis.
Chun-Ming Wong +5 more
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SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. [PDF]
PLoS ONE, 2010 DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have
Dawei Gou +7 more
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Genetic and DNA methylation changes in cotton (Gossypium) genotypes and tissues. [PDF]
PLoS ONE, 2014 In plants, epigenetic regulation is important in normal development and in modulating some agronomic traits. The potential contribution of DNA methylation mediated gene regulation to phenotypic diversity and development in cotton was investigated between
Kenji Osabe +7 more
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Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. [PDF]
PLoS ONE, 2010 Global loss of DNA methylation and locus/gene-specific gain of DNA methylation are two distinct hallmarks of carcinogenesis. Aberrant DNA methylation is implicated in smoking-related lung cancer.
Stella Tommasi +5 more
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Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta. [PDF]
PLoS ONE, 2014 A small number of recent reports have suggested that altered placental DNA methylation may be associated with early onset preeclampsia. It is important that further studies be undertaken to confirm and develop these findings.
Tianjiao Chu +6 more
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Influence of genetic background and tissue types on global DNA methylation patterns. [PDF]
PLoS ONE, 2010 Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively ...
Howard H Yang +7 more
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DNA methylation heterogeneity induced by collaborations between enhancers [PDF]
Journal of Computational Biology, 2020, 2020 During mammalian embryo development, reprogramming of DNA methylation plays important roles in the erasure of parental epigenetic memory and the establishment of na\"{i}ve pluripogent cells. Multiple enzymes that regulate the processes of methylation and demethylation work together to shape the pattern of genome-scale DNA methylation and guid the ...
arxiv +1 more source