The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status [PDF]
eLife, 2017 DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Dongming Li +20 more
doaj +5 more sources
Versatile molecular tools enabling customizable DNA methylation editing in Arabidopsis [PDF]
Nature CommunicationsTools to edit DNA methylation in a targeted manner are vital for establishing causal relationships between DNA methylation and its function, as well as for plant breeding and gene therapy.
Li He +7 more
doaj +2 more sources
Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing [PDF]
Journal of Epigenetics, 2022 Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection.
Samina Gul, Tang Wenru
doaj +1 more source
Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. [PDF]
PLoS ONE, 2011 DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis.
Chun-Ming Wong +5 more
doaj +1 more source
DunedinPACE, a DNA methylation biomarker of the pace of aging
eLife, 2021 Background: Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans.
Daniel W Belsky +19 more
semanticscholar +1 more source
SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. [PDF]
PLoS ONE, 2010 DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have
Dawei Gou +7 more
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Influence of genetic background and tissue types on global DNA methylation patterns. [PDF]
PLoS ONE, 2010 Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively ...
Howard H Yang +7 more
doaj +1 more source
Sarcoma classification by DNA methylation profiling
Nature Communications, 2021 Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features.
C. Koelsche +110 more
semanticscholar +1 more source
Genetic and DNA methylation changes in cotton (Gossypium) genotypes and tissues. [PDF]
PLoS ONE, 2014 In plants, epigenetic regulation is important in normal development and in modulating some agronomic traits. The potential contribution of DNA methylation mediated gene regulation to phenotypic diversity and development in cotton was investigated between
Kenji Osabe +7 more
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Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]
, 2014 peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core +4 more sources