Results 1 to 10 of about 2,686,549 (398)

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status [PDF]

eLife, 2017
DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Dongming Li, Ana Marie S Palanca, So Youn Won, Lei Gao, Ying Feng, Ajay A Vashisht, Li Liu, Yuanyuan Zhao, Xigang Liu, Xiuyun Wu, Shaofang Li, Brandon Le, Yun Ju Kim, Guodong Yang, Shengben Li, Jinyuan Liu, James A Wohlschlegel, Hongwei Guo, Beixin Mo, Xuemei Chen, Julie A Law   +20 more
doaj   +5 more sources

DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities [PDF]

Clinical Epigenetics
Abnormal DNA methylation is a hallmark of cancer and a nearly universal feature of melanoma. DNA methylation plays well-appreciated melanoma cell-intrinsic roles, including silencing tumor-suppressor genes, regulating genomic stability, deregulating ...
Maya G. Deshmukh, Veronica T. Brooks, Simon F. Roy, Simon Milette, Marcus Bosenberg, Goran Micevic   +5 more
doaj   +2 more sources

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development [PDF]

Cell, 1999
Masaki Okano, Daphne W. Bell, Daniel A. Haber, En Li   +3 more
openalex   +2 more sources

Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing [PDF]

Journal of Epigenetics, 2022
Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection.
Samina Gul, Tang Wenru
doaj   +1 more source

Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. [PDF]

PLoS ONE, 2011
DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis.
Chun-Ming Wong, Carmen Chak-Lui Wong, Yeung-Lam Ng, Sandy Leung-Kuen Au, Frankie Chi-Fat Ko, Irene Oi-Lin Ng   +5 more
doaj   +1 more source

DunedinPACE, a DNA methylation biomarker of the pace of aging

eLife, 2021
Background: Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans.
Daniel W Belsky, A. Caspi, D. Corcoran, K. Sugden, R. Poulton, L. Arseneault, A. Baccarelli, K. Chamarti, Xu Gao, E. Hannon, H. Harrington, R. Houts, M. Kothari, D. Kwon, J. Mill, J. Schwartz, P. Vokonas, Cuicui Wang, Benjamin S. Williams, T. Moffitt   +19 more
semanticscholar   +1 more source

SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. [PDF]

PLoS ONE, 2010
DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have
Dawei Gou, Monica Rubalcava, Silvia Sauer, Felipe Mora-Bermúdez, Hediye Erdjument-Bromage, Paul Tempst, Elisabeth Kremmer, Frank Sauer   +7 more
doaj   +1 more source

Influence of genetic background and tissue types on global DNA methylation patterns. [PDF]

PLoS ONE, 2010
Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively ...
Howard H Yang, Nan Hu, Chaoyu Wang, Ti Ding, Barbara K Dunn, Alisa M Goldstein, Philip R Taylor, Maxwell P Lee   +7 more
doaj   +1 more source

Sarcoma classification by DNA methylation profiling

Nature Communications, 2021
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features.
C. Koelsche, D. Schrimpf, D. Stichel, M. Sill, F. Sahm, D. Reuss, Mirjam Blattner, Barbara C. Worst, C. Heilig, K. Beck, P. Horák, S. Kreutzfeldt, Elke Paff, S. Stark, P. Johann, F. Selt, J. Ecker, D. Sturm, K. Pajtler, A. Reinhardt, A. Wefers, P. Sievers, A. Ebrahimi, A. Suwala, F. Fernández-Klett, B. Casalini, A. Korshunov, V. Hovestadt, F. Kommoss, M. Kriegsmann, M. Schick, M. Bewerunge-Hudler, T. Milde, O. Witt, A. Kulozik, M. Kool, L. Romero-Pérez, T. G. Grünewald, T. Kirchner, W. Wick, M. Plattén, A. Unterberg, M. Uhl, A. Abdollahi, J. Debus, B. Lehner, C. Thomas, M. Hasselblatt, W. Paulus, C. Hartmann, O. Staszewski, M. Prinz, J. Hench, S. Frank, Y. Versleijen-Jonkers, M. Weidema, T. Mentzel, K. Griewank, E. de Álava, Juan Díaz Martín, M. I. Gastearena, K. Chang, S. Low, Adrián Cuevas-Bourdier, M. Mittelbronn, M. Mynarek, S. Rutkowski, U. Schüller, V. Mautner, J. Schittenhelm, J. Serrano, M. Snuderl, R. Büttner, T. Klingebiel, R. Buslei, M. Gessler, P. Wesseling, W. Dinjens, S. Brandner, Z. Jaunmuktane, Iben Lyskjær, P. Schirmacher, A. Stenzinger, B. Brors, H. Glimm, C. Heining, Ò. M. Tirado, Miguel Sáinz-Jaspeado, J. Mora, J. Alonso, X. G. del Muro, S. Moran, M. Esteller, J. Benhamida, M. Ladanyi, E. Wardelmann, C. Antonescu, A. Flanagan, U. Dirksen, P. Hohenberger, D. Baumhoer, W. Hartmann, C. Vokuhl, U. Flucke, I. Petersen, G. Mechtersheimer, D. Capper, David T. W. Jones, S. Fröhling, S. Pfister, A. von Deimling   +110 more
semanticscholar   +1 more source

A Feature Selection Algorithm to Compute Gene Centric Methylation from Probe Level Methylation Data [PDF]

, 2016
DNA methylation is an important epigenetic event that effects gene expression during development and various diseases such as cancer. Understanding the mechanism of action of DNA methylation is important for downstream analysis.
Baur, Brittany, Bozdag, Serdar
core   +9 more sources