Results 1 to 10 of about 648,959 (323)

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status [PDF]

eLife, 2017
DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Dongming Li, Ana Marie S Palanca, So Youn Won, Lei Gao, Ying Feng, Ajay A Vashisht, Li Liu, Yuanyuan Zhao, Xigang Liu, Xiuyun Wu, Shaofang Li, Brandon Le, Yun Ju Kim, Guodong Yang, Shengben Li, Jinyuan Liu, James A Wohlschlegel, Hongwei Guo, Beixin Mo, Xuemei Chen, Julie A Law   +20 more
doaj   +5 more sources

DNA methylation and DNA methyltransferases [PDF]

Epigenetics & Chromatin, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +9 more sources

Versatile molecular tools enabling customizable DNA methylation editing in Arabidopsis [PDF]

Nature Communications
Tools to edit DNA methylation in a targeted manner are vital for establishing causal relationships between DNA methylation and its function, as well as for plant breeding and gene therapy.
Li He, Yao Yao, Yin You, Xiaofei Wei, Yu Ma, Wei Yuan, Zhaobo Lang, Jian-Kang Zhu   +7 more
doaj   +2 more sources

Highlight DNA Methylation Biomarkers in Different Cancer Type for Drug Designing [PDF]

Journal of Epigenetics, 2022
Recently the study of epigenetics is related to diverse processes such as chromatin structure, tumorigenesis, transcriptional regulation, and genome integrity. Epigenetics defect is one of a new area of cancer detection.
Samina Gul, Tang Wenru
doaj   +1 more source

Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. [PDF]

PLoS ONE, 2011
DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis.
Chun-Ming Wong, Carmen Chak-Lui Wong, Yeung-Lam Ng, Sandy Leung-Kuen Au, Frankie Chi-Fat Ko, Irene Oi-Lin Ng   +5 more
doaj   +1 more source

DNA Methylation [PDF]

EcoSal Plus, 2009
The DNA of Escherichia coli contains 19,120 6-methyladenines and 12,045 5-methylcytosines in addition to the four regular bases, and these are formed by the postreplicative action of three DNA methyltransferases. The majority of the methylated bases are formed by the Dam and Dcmmethyltransferases encoded by the
Marinus, Martin G., Løbner-Olesen, Anders   +1 more
openaire   +4 more sources

SETDB1 is involved in postembryonic DNA methylation and gene silencing in Drosophila. [PDF]

PLoS ONE, 2010
DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have
Dawei Gou, Monica Rubalcava, Silvia Sauer, Felipe Mora-Bermúdez, Hediye Erdjument-Bromage, Paul Tempst, Elisabeth Kremmer, Frank Sauer   +7 more
doaj   +1 more source

Methylated DNA Immunoprecipitation [PDF]

Journal of Visualized Experiments, 2009
The identification of DNA methylation patterns is a common procedure in the study of epigenetics, as methylation is known to have significant effects on gene expression, and is involved with normal development as well as disease. Thus, the ability to discriminate between methylated DNA and non-methylated DNA is essential for generating methylation ...
Kelsie L, Thu, Emily A, Vucic, Jennifer Y, Kennett, Cameron, Heryet, Carolyn J, Brown, Wan L, Lam, Ian M, Wilson   +6 more
openaire   +2 more sources

Influence of genetic background and tissue types on global DNA methylation patterns. [PDF]

PLoS ONE, 2010
Recent studies have shown a genetic influence on gene expression variation, chromatin, and DNA methylation. However, the effects of genetic background and tissue types on DNA methylation at the genome-wide level have not been characterized extensively ...
Howard H Yang, Nan Hu, Chaoyu Wang, Ti Ding, Barbara K Dunn, Alisa M Goldstein, Philip R Taylor, Maxwell P Lee   +7 more
doaj   +1 more source

Genetic and DNA methylation changes in cotton (Gossypium) genotypes and tissues. [PDF]

PLoS ONE, 2014
In plants, epigenetic regulation is important in normal development and in modulating some agronomic traits. The potential contribution of DNA methylation mediated gene regulation to phenotypic diversity and development in cotton was investigated between
Kenji Osabe, Jenny D Clement, Frank Bedon, Filomena A Pettolino, Lisa Ziolkowski, Danny J Llewellyn, E Jean Finnegan, Iain W Wilson   +7 more
doaj   +1 more source