Results 31 to 40 of about 151,241 (263)

Epigenetic aging in cows is accelerated by milk production

Epigenetics, 2023
DNA methylation has proven to be the most promising age-predictive biomarker in mammals resulting in the emergence of ‘epigenetic clocks’ that describe the relationship between methylation levels and age. Using Targeted bisulfite Sequencing, we evaluated
Prashansa Ratan, Liudmilla Rubbi, Michael Thompson, Kaushik Naresh, Jolena Waddell, Barbara Jones, Matteo Pellegrini   +6 more
doaj   +1 more source

Klotho Gene, Aging and DNA Methylation

Journal of Marmara University Institute of Health Sciences, 2014
Doğal bir süreç olan yaşlanma, zamanın akışı içerisinde canlı organizmada görülen anatomik ve fizyolojik değişiklikler olarak kendini gösterir. Yaşlanma sürecinde hem çevresel hem de genetik faktörler etkili olur. Genetik faktörler arasında farklı metabolik yolakları kontrol eden birçok gen yer alır.
ÇAĞLAYAN, Elif, TURAN, Kadir
openaire   +2 more sources

DNA methylation controls hematopoietic stem cell aging

Nature Aging, 2023
Epigenome deregulation is considered a hallmark of aging; however, the function of the alteration of DNA methylation in aged tissues is a long-standing question. Hong and colleagues reveal the mechanism and consequences of DNA methylation loss at heterochromatin regions in aged hematopoietic stem cells.
Krepelova, A, Neri, F
openaire   +2 more sources

DNA Methylation Biomarkers in Aging and Age-Related Diseases [PDF]

Frontiers in Genetics, 2020
Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease. It is currently well established that DNA methylation biomarkers can determine biological age of any tissue across the entire human lifespan, even during development.
Yasmeen Salameh, Yosra Bejaoui, Nady El Hajj   +2 more
openaire   +3 more sources

Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study

Epigenetics, 2023
The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are not well studied
Allison Reiner, Kelly M. Bakulski, Jonah D. Fisher, John F Dou, Lisa Schneper, Colter Mitchell, Daniel A. Notterman, Matthew Zawistowski, Erin B. Ware   +8 more
doaj   +1 more source

Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes

Frontiers in Genetics, 2019
The biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was initially considered a promising biomarker for the prediction of ...
Fu-Hui Xiao, Fu-Hui Xiao, Fu-Hui Xiao, Fu-Hui Xiao, Fu-Hui Xiao, Hao-Tian Wang, Hao-Tian Wang, Hao-Tian Wang, Hao-Tian Wang, Hao-Tian Wang, Hao-Tian Wang, Qing-Peng Kong, Qing-Peng Kong, Qing-Peng Kong, Qing-Peng Kong, Qing-Peng Kong   +15 more
doaj   +1 more source

DNA Methylation Modulates Aging Process in Adipocytes

Aging and disease, 2022
Aging has been recognized to be a highly complex biological health problem with a high risk of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or emphysema, cancer and Alzheimer's disease. Particularly, age-related turnover in adipose tissue is a major contributor to metabolic syndromes and shortened lifespan ...
Xie, Hao, Liu, Xin, Zhou, Qing, Huang, Teng, Zhang, Lu, Gao, Jia, Wang, Yuhan, Liu, Yanjun, Yan, Tong, Zhang, Shu, Wang, Cong-Yi   +10 more
openaire   +2 more sources

Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa. [PDF]

PLoS ONE, 2016
DNA methylation plays important roles in the production and functioning of spermatozoa. Recent studies have suggested that DNA methylation patterns in spermatozoa can change with age, but the regions susceptible to age-related methylation changes remain ...
Norio Kobayashi, Hiroaki Okae, Hitoshi Hiura, Hatsune Chiba, Yoshiki Shirakata, Kenshiro Hara, Kentaro Tanemura, Takahiro Arima   +7 more
doaj   +1 more source

Role of Age-Related Changes in DNA Methylation in the Disproportionate Susceptibility and Worse Outcomes of Sepsis in Older Adults

Frontiers in Medicine, 2022
Sepsis, a complex multisystem disorder, is among the top causes of hospitalization and mortality in older adults. However, the mechanisms underlying the disproportionate susceptibility to sepsis and worse outcomes in the elderly are not well understood ...
Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Lingling Shen, Lingling Shen, Lingling Shen, Lingling Shen, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Yang Chen, Yang Chen, Yang Chen, Yang Chen, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Qun Su, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Francesco Neri, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen   +41 more
doaj   +1 more source

Aging, DNA methylation and cancer

Critical Reviews in Oncology/Hematology, 1999
2. DNA methylation patterns in normal cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 2.1. Normal DNA methylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 2.2. CpG islands . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
openaire   +2 more sources