Results 231 to 240 of about 71,628 (244)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Clinicopathological Significance of Defective DNA Mismatch Repair in Endometrial Carcinoma: A Single-Center Study From Bahrain. [PDF]

Cureus
Hammad M, Almahari SAI, Umakanth S, Toorani ZA.   +3 more
europepmc   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, EarlyView.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer. [PDF]

Cell Rep Med
Nowak M, Jabbar F, Rodewald AK, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders M, Kerr R, Oein K, Maka N, Hay J, Edwards J, Tomlinson I, Sansom O, Kelly C, Pezzella F, Kerr D, Easton A, Domingo E, TransSCOT group, Koelzer VH, Church DN.   +22 more
europepmc   +1 more source

Harmonising digitised herbarium data to enhance biodiversity knowledge: Major steps towards an updated checklist for the flora of Greenland

PLANTS, PEOPLE, PLANET, EarlyView.
Herbaria worldwide hold centuries of plant data that are key to understanding and protecting biodiversity; however, even with increased digital access, differences in plant naming systems make it difficult to compare records. We developed a semi‐automated workflow that standardises species names and organises herbaria records from multiple institutions
Brandon Samuel Whitley, Jakob Abermann, Inger Greve Alsos, Elisabeth M. Biersma, Viktor Gårdman, Toke Thomas Høye, Laura Jones, Nora Meriem Khelidj, Zhao Li, Gianalberto Losapio, Thomas Pape, Katrine Raundrup, Paula Schmitz, Tiago Silva, Helena Wirta, Tomas Roslin, Natalie Iwanycki Ahlstrand, Natasha de Vere   +17 more
wiley   +1 more source

Leveraging machine learning and citizen science data to describe flowering phenology across South Africa

PLANTS, PEOPLE, PLANET, EarlyView.
Recent shifts in flowering times are an index of, and a response to, human driven climate change. However, most information on these flowering changes is heavily skewed to the northern hemisphere. This imbalance limits our understanding of how climate change is affecting ecosystems, including the mismatches of flowering times between species, increased
Ross D. Stewart, Nicholas W. Bard, Michelle van der Bank, T. Jonathan Davies   +3 more
wiley   +1 more source

Soil properties and road proximity likely influence plant and bacterial traits and diversity more than habitat size in small urban greenspaces

PLANTS, PEOPLE, PLANET, EarlyView.
The global decline in biodiversity can be partly ameliorated by sympathetic design of green spaces within urban environments. This includes roundabouts on road systems. This study utilised a combination of approaches to assess levels of plant and bacterial diversity in roundabouts of varying size, soil characteristics and habitat complexity.
Ethan Mitchell‐Innes, Brady Locke‐King, Michelle L. Davis, Paul Ashton, Ellen L. Fry   +4 more
wiley   +1 more source

MutLα suppresses error-prone DNA mismatch repair and preferentially protects noncoding DNA from mutations. [PDF]

J Biol Chem
Kadyrova LY, Mieczkowski PA, Kadyrov FA.
europepmc   +1 more source

CDK-independent role of D-type cyclins in regulating DNA mismatch repair. [PDF]

Mol Cell
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M.   +23 more
europepmc   +1 more source

Response to immune checkpoint inhibition in a meningioma with DNA mismatch repair deficiency. [PDF]

Neurooncol Adv
Nguyen MP, Almiron Bonnin D, Mirchia K, Chen WC, Goldschmidt E, Braunstein SE, Perry A, Raleigh DR, Oberheim Bush NA.   +8 more
europepmc   +1 more source