Results 1 to 10 of about 8,812 (165)
Frontiers in Microbiology, 2023 DNA methylation events mediated by orphan methyltransferases modulate various cellular processes like replication, repair and transcription. Bacteria and archaea also harbor DNA methyltransferases that are part of restriction-modification systems, which ...
Pallavi Gulati +3 more
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Genome-Wide Identification of DNA Methylases and Demethylases in Kiwifruit (Actinidia chinensis)
Frontiers in Plant Science, 2020 DNA methylation plays an important role in a wide range of developmental and physiological processes in plants. It is primarily catalyzed and regulated by cytosine-5 DNA methyltransferases (C5-MTases) and a group of DNA glycosylases that act as ...
Yaoxin Zhang +12 more
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Biomolecules, 2022 Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti +4 more
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Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions
Molecules, 2021 DNA methyltransferases (DNMTs) including DNMT1 are a conserved family of cytosine methylases that play crucial roles in epigenetic regulation. The versatile functions of DNMT1 rely on allosteric networks between its different interacting partners ...
Yu Zhu +5 more
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Substrate recognition and selectivity in the type IC DNA modification methylase M.EcoR124l [PDF]
Nucleic Acids Research, 1993 The type I DNA modification methylase M.EcoR124I binds sequence specifically to DNA and protects a 25bp fragment containing its cognate recognition sequence from digestion by exonuclease III. Using modified synthetic oligonucleotide duplexes we have investigated the catalytic properties of the methylase, and have established that a specific adenine on ...
I, Taylor, D, Watts, G, Kneale
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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase [PDF]
Proceedings of the National Academy of Sciences, 2006 We used engineered zinc finger peptides (ZFPs) to bind selectively to predetermined sequences in human mtDNA. Surprisingly, we found that engineered ZFPs cannot be reliably routed to mitochondria by using only conventional mitochondrial targeting sequences.
Michal, Minczuk +4 more
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Mechanism of RNA modification N6-methyladenosine in human cancer
Molecular Cancer, 2020 Since the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a predominantly internal epigenetic modification in
Zijian Zhou +9 more
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Cytosine modification in DNA by BcnI methylase yields N4‐methylcytosine [PDF]
FEBS Letters, 1983 A. Janulaitis, S. KlimaSauskas, M. PetruSyte and V. Butkus Institute of Applied Enzymology, 232028 Vilnius, Fermentu 8, Lithuanian SSR, USSR Received 11 July 1983 Abstract and keywords not received 1. INTRODUCTION The means by which bacteria protect their own DNA from their restriction enzymes have not been fully investigated.
Janulaitis, A. +3 more
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DNA Modification Methylase Activity of Escherichia coli Restriction Endonucleases K and P [PDF]
Proceedings of the National Academy of Sciences, 1972 The highly purified restriction endonucleases of E. coli K and coliphage P1 transfer methyl groups from S -adenosylmethionine to adenine residues of unmodified DNA. Incubation of unmodified DNA with endonucleases K or P and S -adenosylmethionine renders the DNA ...
A, Haberman, J, Heywood, M, Meselson
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Enzymatic DNA modification in vitro: Cytosine methylation in heterologous DNAs by different DNA methylase fractions from E. coli [PDF]
FEBS Letters, 1974 The biological function of the majority of methylated bases in DNAs is still unknown [ 1,2]. Recently Roy and Smith purified and characterized four DNA-adenine methylases from Hemophilus injluensue Rd [3]. Evidently, the bacterial cell also contains several DNA-cytosine methylases which methylate cytosine in several nucleotide sequences.
Buryanov, Y.I. +3 more
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