Results 41 to 50 of about 8,812 (165)

The Role of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis Advanced Lung Disease

Transplant Infectious Disease, EarlyView.
Among 270 cystic fibrosis patients, 20.7% were NTM‐positive and had a lower pre‐transplant risk of death or lung transplantation but higher post‐transplant mortality, with no difference in CLAD incidence. These results suggest NTM infection should not be an absolute contraindication to lung transplantation, though careful individual risk assessment is ...
Shirin Barcikowski, Ribal Bou Mjahed, Oriol Manuel, Macé M. Schuurmans, Adrian Alonso, Zisis Balmpouzis, Jesica Mazza‐Stalder, Angela Koutsokera, Nicolas J. Mueller   +8 more
wiley   +1 more source

Sequence-specific DNA binding by the MspI DNA methyltransferase [PDF]

, 1992
The MspI methyltransferase (M.MspI) recognizes the sequence CCGG and catalyzes the formation of 5-methylcytosine at the fist C-residue. We have investigated the sequence-specific DNA-binding properties of M.MspI under equilibrium conditions, using gel ...
Dubey, A. K., Roberts, R. J.
core   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, Volume 13, Issue 20, 9 April 2026.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Complete Genome Sequence of Curtobacterium sp. Strain MR_MD2014, Isolated from Topsoil in Woods Hole, Massachusetts [PDF]

, 2015
Here, we present the 3,443,800-bp complete genome sequence of Curtobacterium sp. strain MR_MD2014 (phylum Actinobacteria). This strain was isolated from soil in Woods Hole, MA, as part of the 2014 Microbial Diversity Summer Program at the Marine ...
Bhatnagar, Srijak, Boitano, Matthew, Dawson, Scott C., Hanselmann, Kurt, Hossain, Mohammad J., Korlach, Jonas, Leadbetter, Jared R., Liles, Mark R., Mariita, Richard M., Moss, Anthony G., Newman, Dianne K., Roberts, Richard J.   +11 more
core   +3 more sources

Genome‐Wide 6mA Map Unveils Epigenetic Adaptation in Deep‐Sea Limpet

Ecology and Evolution, Volume 16, Issue 4, April 2026.
Our study provides the first genome‐wide 6mA profile for any deep‐sea animal, uncovers its sophisticated, context‐dependent role in gene regulation, and functionally links this epigenetic mark to the adaptive pathways essential for deep‐sea survival.
Chengqin Chen, Jianhui Liu, Ruhao Zhuang, Kuo Ni, Minxiao Wang, Yuli Li, Jing Wang, Shi Wang, Wentao Han, Lisui Bao   +9 more
wiley   +1 more source

An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes

Iranian Journal of Medical Sciences, 2018
Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a
Mehdi Nikbakht Dastjerdi, Asaad Azarnezhad, Batool Hashemibeni, Mansour Salehi, Mohammad Kazemi, Zahra Babazadeh   +5 more
doaj  

The EcoKI Type I Restriction-Modification System in Escherichia coli Affects but Is Not an Absolute Barrier for Conjugation. [PDF]

, 2015
The rapid evolution of bacteria is crucial to their survival and is caused by exchange, transfer, and uptake of DNA, among other things. Conjugation is one of the main mechanisms by which bacteria share their DNA, and it is thought to be controlled by ...
Aarestrup, Frank Møller, Hasman, Henrik, Roer, Louise   +2 more
core   +1 more source

Comparative Proteomic Profiling of Clinical Klebsiella pneumoniae Strains and the Corresponding Outer Membrane Vesicles

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Klebsiella pneumoniae (K. pneumoniae) has become a global threat due to the convergence of carbapenem resistance and hypervirulence. Outer membrane vesicles (OMVs) play important roles in bacterial pathogenicity, yet their functional coordination with strains remains unclear.
Zongping Li, Jingyuan Xi, Xinmiao Jia, Yangzhige He, Guibin Wang, Shiyu Chen, Xiaobing Chu, Qian Zhang, Ying Zhu, Wei Yu, Peiyao Jia, Xiaoyu Liu, Qiwen Yang   +12 more
wiley   +1 more source

Comparative genomics of Cluster O mycobacteriophages [PDF]

, 2015
Mycobacteriophages - viruses of mycobacterial hosts - are genetically diverse but morphologically are all classified in the Caudovirales with double-stranded DNA and tails.
Adair, T, Anders, KR, Ball, S, Bollivar, D, Bowman, CA, Breitenberger, C, Burnett, SH, Butela, K, Byrnes, D, Carzo, S, Cornely, KA, Cresawn, SG, Cross, T, Daniels, RL, De Los Santos, C, Dedrick, RM, Dunbar, D, Ekanem, K, Findley, AM, Gissendanner, CR, Golebiewska, UP, Hartzog, GA, Hatfull, GF, Hatherill, JR, Hendrix, RW, Hughes, LE, Jacobs-Sera, D, Jalloh, CS, Khambule, SL, King, RA, King-Smith, C, Klyczek, K, Krukonis, GP, Laing, C, Lapin, JS, Lopez, AJ, Mkhwanazi, SM, Molloy, SD, Moran, D, Munsamy, V, Pacey, E, Plymale, R, Pope, WH, Poxleitner, M, Reyna, N, Russell, DA, Schildbach, JF, Stukey, J, Taylor, SE, Ware, VC, Wellmann, AL, Westholm, D, Wodarski, D, Zajko, M, Zikalala, TS   +54 more
core   +1 more source

Epigenetics—Innovations and Misconceptions

Natural Sciences, Volume 6, Issue 2, April 2026.
ABSTRACT Epigenetics is a scientific field whose definition has changed over time. Established in the 1940s by C.H. Waddington by synthesis from embryology and genetics, the term “epigenetics” is now mainly used to describe the role of chromatin modifications in the regulation and perpetuation of gene activity states.
Bernhard Horsthemke
wiley   +1 more source