Results 61 to 70 of about 8,812 (165)

A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research

International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.
Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez, Isabel Sierra, Jop Kind   +2 more
wiley   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI. [PDF]

, 2012
DNA methylation-dependent restriction enzymes have many applications in genetic engineering and in the analysis of the epigenetic state of eukaryotic genomes.
Bochtler, Matthias, Bujnicki, Janusz M, Czapinska, Honorata, Siwek, Wojciech, Skowronek, Krzysztof   +4 more
core   +1 more source

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

The FEBS Journal, Volume 293, Issue 1, Page 10-25, January 2026.
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley   +1 more source

DNA methylases for site-selective inhibition of type IIS restriction enzyme activity. [PDF]

Appl Microbiol Biotechnol
Flores-Fernández CN, Lin D, Robins K, O'Callaghan CA.   +3 more
europepmc   +2 more sources

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline [PDF]

, 2003
BACKGROUND: Differential methylation of the two alleles is a hallmark of imprinted genes. Correspondingly, loss of DNA methyltransferase function results in aberrant imprinting and abnormal post-fertilization development.
Bonthron, D.T., De Vos, M., Hayward, B. E., Hodge, D., Huntriss, J., Judson, H., Picton, H.M., Sheridan, E.   +7 more
core   +3 more sources

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source

Genotype‐dependent DNA methylation patterns are negatively associated with allelic variation rather than heat‐induced gene expression in two contrasting potato genotypes

The Plant Journal, Volume 125, Issue 2, January 2026.
SUMMARY Potato (Solanum tuberosum L.) is an important food crop that is sensitive to high temperatures, which cause major changes in the transcriptome and a reduction in yield. In several plant species, DNA methylation has been reported to influence gene expression, particularly under abiotic stress conditions.
Darren Sheng Gin Yeo, Julia Eydam, Julien Bruckmüller, Friedrich Kauder, Jens Lübeck, Alexander Kaier, Sophia Sonnewald, Uwe Sonnewald   +7 more
wiley   +1 more source

Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5 [PDF]

, 2015
Molecular Technology and Informatics for Personalised Medicine and ...
Adam P Roberts, Arnoud M Schmitz, Erika van Eijk, Hilary P Browne, Jeroen Frank, Seyed Anvar, Wai Leung, Wiep Smits   +7 more
core   +1 more source

Resolving the complete genome of Kuenenia stuttgartiensis from a membrane bioreactor enrichment using Single-Molecule Real-Time sequencing [PDF]

, 2017
Contains fulltext : 190074.pdf (publisher's version ) (Open Access)10 ...
Frank, J., Lücker, S., Vossen, Rolf H.A.M., Jetten, M.S.M., Hall, Richard J., Camp, H.J.M.O. den, Anvar, Seyed Yahya   +6 more
core   +3 more sources