Results 51 to 60 of about 8,812 (165)

Strain, procedures, and tools for reproducible genetic transformation and genome editing of the emerging plant model Spirodela polyrhiza

New Phytologist, Volume 250, Issue 2, Page 735-756, April 2026.
Summary Duckweeds (Lemnaceae) have excellent potential for fundamental and applied research due to ease of cultivation, small size, and continuous fast clonal growth. However, their usage as model organisms and platforms for biotechnological applications is often limited by the lack of universal genetic manipulation methods necessary for transgene ...
Verónica Barragán‐Borrero, Amanda de Santana Lopes, Enrico Diniz Rodrigues Batista, Martin Höfer, Rana Elias, Abhisek Chakraborty, Arturo Ponce‐Mañe, Clotilde Descombes, Laura Diezma‐Navas, Lydia Petraki, Meret Huber, Shuqing Xu, Arturo Marí‐Ordóñez   +12 more
wiley   +1 more source

Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler   +17 more
wiley   +1 more source

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source

Exploring Transcriptomic Microsatellite Markers in Hydrangea petiolaris (Hydrangeaceae): A Resource for Population Genetics and Functional Genomic Insights

Ecology and Evolution, Volume 16, Issue 3, March 2026.
This study analyzed the genetic population structure of Hydrangea petiolaris using 28 SSR markers. Distinct genetic clusters were identified, providing valuable insights for the evolution and conservation. Specifically, STRUCTURE analysis revealed clear genetic differentiation, contributing to our understanding of the species' genetic diversity ...
Seongjun Park, Sumi Choi, Saeyeon Hwang, Eun‐Mi Lee, SeonJoo Park   +4 more
wiley   +1 more source

Epigenetics and the estrogen receptor [PDF]

, 2006
The position effect variegation in Drosophila and Schizosaccharomyces pombe, and higher-order chromatin structure regulation in yeast, is orchestrated by modifier genes of the Su(var) group, (e.g., histone deacetylases ([HDACs]), protein phosphatases ...
Bautista S., Bouras T., C. WANG, Cui Y., Dreijerink K.M., Fu M., Fu M., Fu M., Fu M., Fu M., Fu M., Fu M., Fu M., Fu M., Fuqua S.A., Girault I., Hanstein B., Hortobagyi G.N., Hulit J., J. E LEADER, Ju B.G., Kawai H., Kenny F.S., Kim M.Y., Knights C.D., Kraus W.L., Kraus W.L., Kurebayashi J., Leader J.E., Li Z., M. FU, Macaluso M., Michalides R., Paik W.K., R. G PESTELL, Sakamaki T., Sharma D., V. M POPOV, Wang C., Wang C., Wang C., Wang C., Wang C., Wang X., Westwick J.K., Yan P.S., Yang X., Zwijsen R.M.L.   +47 more
core   +2 more sources

Genomics in wheat improvement: Progress and perspectives

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Bread wheat (Triticum aestivum) remains a major source of food and calories globally, yet its vast genome, polyploidy, and high number of repetitive sequences make genomic research challenging in this crop. In this review, we discuss the progress and future perspectives of genome research in wheat. Current efforts focus on the establishment of
Shaoshuai Liu, Shuaifeng Geng, Susanne Dreisigacker   +2 more
wiley   +1 more source

Site-Specific Methylation of Adenine in the Nuclear Genome of a Eucaryote, \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1986
DNA in the polyploid macronucleus of the ciliated protozoan Tetrahymena thermophila contains the modified base N6-methyladenine. We identified two GATC sites which are methylated in most or all of the 45 copies of the macronuclear genome.
Findly, R. Craig, Harrison, Gail Singer, Karrer, Kathleen M.   +2 more
core   +1 more source

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]

, 2015
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia, Saccone, Valentina, Sandona', Martina   +2 more
core   +4 more sources

Characterization of Phytoene Desaturase Knockout Carotenoid‐Deficient Microalgal Mutants Generated by Cas9‐Ribonucleoprotein Complexes

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez, Simon Kelterborn, Peter Hegemann, Miguel Pérez‐Rodríguez, Javier Vigara, Rosa León   +5 more
wiley   +1 more source

Transformation of \u3cem\u3eTetrahymena thermophila\u3c/em\u3e with Hypermethylated rRNA Genes [PDF]

, 1988
The extrachromosomal rRNA genes (rDNA) of Tetrahymena thermophila contain 0.4% N6-methyladenine. C3 strain rDNA was isolated, hypermethylated in vitro, and microinjected into B strain host cells. Clonal cell lines were established, and transformants were
Karrer, Kathleen M., Yao, Meng-Chao
core   +1 more source