Results 101 to 110 of about 5,212,695 (327)

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY, Angelova, PR, Gandhi, S, Horrocks, MH, Klenerman, D, Shchepinov, MS   +5 more
core   +2 more sources

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Biotransformation of docosahexaenoic acid into 10R,17S- dihydroxydocosahexaenoic acid as protectin Dx 10-epimer by serial reactions of arachidonate 8R- and 15S-lipoxygenases [PDF]

, 2023
Tae‐Eui Lee, Yoon‐Joo Ko, Kyung‐Chul Shin, Deok‐Kun Oh   +3 more
openalex   +1 more source

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development*

Journal of Biological Chemistry, 2016
Eye photoreceptor membrane discs in outer rod segments are highly enriched in the visual pigment rhodopsin and the ω-3 fatty acid docosahexaenoic acid (DHA).
B. H. Wong, J. P. Chan, A. Cazenave-Gassiot, R. W. Poh, Juat Chin Foo, D. L. Galam, Sujoy Ghosh, Long N. Nguyen, V. Barathi, S. Yeo, C. Luu, M. Wenk, D. Silver   +12 more
semanticscholar   +1 more source

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
core   +1 more source

A multicountry, multicenter report to identify nutritional risks in female populations using the FIGO Nutrition Checklist

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify potential nutritional risks for women using the FIGO Nutrition Checklist in relation to region, age and pregnancy/intention. Methods A retrospective analysis was conducted using 1515 responses from the online version of the FIGO Nutrition Checklist available on the FIGO website. Participants who responded “No” to at least
Alex K. L. Taylor, Lucy Murphy, Sophie Callanan, Sarah Louise Killeen, Sharleen L. O'Reilly, Hema Divakar, Hamid Jan Bin Jan Mohamed, Mark A. Hanson, Fionnuala M. McAuliffe   +8 more
wiley   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

A single meal has the potential to alter brain oxylipin content. [PDF]

, 2020
Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH, Norman, JE, Otoki, Y, Rutledge, JC, Taha, AY, Zhang, Z   +5 more
core   +1 more source

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

Effects of Docosahexaenoic Acid on Neurotransmission

Biomolecules and Therapeutics, 2012
Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain and a structural component of neuronal membranes. Changes in DHA content of neuronal membranes lead to functional changes in the activity of receptors and other proteins which might be associated with synaptic function.
Tanaka, Kazuhiro, Farooqui, Akhlaq A., Siddiqi, Nikhat J., Alhomida, Abdullah S., Ong, Wei-Yi   +4 more
openaire   +3 more sources