Results 151 to 160 of about 41,199 (244)

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

ω‐3PUFAs Inhibit Gallbladder Cancer Through Enhancing STK31 Methylation

Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.
ABSTRACT Gallbladder cancer (GBC) is an aggressive malignancy with limited treatment options. ω‐3PUFAs have known anticancer activity, but their role in GBC remains unclear. The anti‐GBC effects of ω‐3PUFAs (DHA/EPA) were evaluated using in vitro assays and mouse xenograft models.
Shuang‐Xing Li, Wei‐Yu Zhu, Hai‐Ying Peng, Bin Zhang, Zhu‐Ying Lin, Song‐Lin Yang, Yi‐Yi Zhao, Hui Gao, Shan He, Yuan Liu, Xiao‐Dan Wang, Yang‐Fan Guo, Wen‐Ju Wang, Zong‐Liu Hou, Ming‐Yao Meng, Li‐Wei Liao, Lin Li   +16 more
wiley   +1 more source

Omega‐3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Álex Pérez‐Sánchez, Mireia Garcia‐Viloca, Àngels González‐Lafont, José M. Lluch   +3 more
wiley   +1 more source

Supplementation with eicosapentaenoic and docosahexaenoic acids in late gestation in ewes changes adipose tissue gene expression in the ewe and growth and plasma concentration of ghrelin in the offspring1. [PDF]

J Anim Sci, 2019
Nickles KR, Hamer L, Coleman DN, Relling AE.   +3 more
europepmc   +1 more source

Issue Information

Food Biomacromolecules, Volume 3, Issue 2, Page 205-208, June 2026.
No abstract is available for this article.
wiley   +1 more source

Early‐Life Nutritional Supplements, Household Environments, and Air Pollution Associated With Children's Helicobacter pylori Infection: A Chinese Multicenter Mother‐Child Study

Safety Science and Technology, Volume 1, Issue 2, June 2026.
Early‐life intake of nutritional additives, particularly during pregnancy and the early postnatal period, reduces the risk of Helicobacter pylori infection (HPI) in children by enhancing immune function and preventing gastrointestinal infections through proper nutrition, supporting the “(Pre‐)Fetal origins of HPI” hypothesis through the “gut–uterine ...
Chan Lu, Yufang Shan, Yuanqi Li, Wen Deng, Yuqing Chen, Yao Chen   +5 more
wiley   +1 more source

Lipase Stability in Structured Lipid Synthesis: The Interplay of Substrate Characteristics and Strategies to Improve Its Operational Performance—A Critical Review

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT Structured lipids (SLs) have attracted growing industrial interest due to their associated health benefits. Lipases, as highly selective and versatile biocatalysts, are central to the sustainable synthesis of SLs attributed to their ability to operate under mild reaction conditions. However, the limited operational stability of lipases remains
Evelyn Ling Lee, Eng‐Seng Chan, Lee Fong Siow, Cher Pin Song, Yee‐Ying Lee   +4 more
wiley   +1 more source

Maternal Intake of Dipteryx alata Vog. Reduces Offspring's Brain Oxidative Stress and Anxiety: Insights From In Silico and In Vivo Studies

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT We undertook a computational investigation and evaluation of the impact of maternal supplementation with baru almonds (Dipteryx alata Vog.) on anxiety‐like behavior and oxidative stress in the brains of adolescent and adult rat offspring. Molecular docking studies were conducted and revealed that the phenolic compounds (PCs) from the baru ...
Diego Elias Pereira, Rita de Cássia de Araújo Bidô, Maciel da Costa Alves, Renally de Lima Moura, Ana Carolina dos Santos Costa, Larissa Maria Gomes Dutra, Louis Gustavo da Costa Sobral e Sá, Vanessa Bordin Viera, Jaqueline Ferreira Ramos, Juliano Carlo Rufino Freitas, Daline Fernandes de Araújo, Gerlane Coelho Bernardo Guerra, Juliana Késsia Barbosa Soares   +12 more
wiley   +1 more source

Nutritional, Oxidative, and Sensory Quality of Whiteleg (Penaeus vannamei) and Pink Shrimp (Penaeus paulensis) From Different Production Systems During Frozen Storage

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT This study compared the nutritional composition, fatty acid profile, oxidative stability, and sensory quality of whiteleg shrimp (Penaeus vannamei) and pink shrimp (Penaeus paulensis) obtained from semi‐intensive, organic, and wild systems. Four groups were evaluated: Semi‐intensive P.
Sarita Correa Rosa, Milena Padilha, Bibiana Alves dos Santos, Pamela Cristiele Oliveira Trindade, Géssica Hollweg, Manoela Meira Balzan, Priscila Rossato Fracari, Alexandre José Cichoski, Roger Wagner, Natalia Fernandes Pereira, Giovanni Lemos de Mello, Márcio Vargas‐Ramella, Paulo Cezar Bastianello Campagnol   +12 more
wiley   +1 more source

Tubular Omega‐3 Fatty Acid Receptor FFAR4 Deficiency Aggravated Renal Aging and Chronic Kidney Disease

Aging Cell, Volume 25, Issue 6, June 2026.
This study illustrates that omega‐3 PUFAs with their receptor FFAR4 alleviate tubular senescence and fibrosis in aged and fibrotic kidneys. Furthermore, we indicate that tubular FFAR4 improves renal senescence via 15d‐PGJ2‐PPARγ‐Klotho signaling, and suppresses kidney fibrosis by senescent tubular cell‐driven fibroblast activation.
Letian Yang, Lei Tang, Jian Li, Dekai Liu, Chunchun Hu, Fan Guo, Lin Lin, Rongshuang Huang, Ping Fu, Liang Ma   +9 more
wiley   +1 more source