Results 91 to 100 of about 37,774 (258)

Bayesian Value-of-Information Analysis: An Application to a Policy Model of Alzheimer's Disease [PDF]

A framework is presented which distinguishes the conceptually separate decisions of which treatment strategy is optimal from the question of whether more information is required to inform this choice in the future.
K. Claxton, M. C. Weinstein, P. J. Neumannn, S. S. Araki   +3 more
core  

Deep cervical lymphatic–venous anastomosis attenuates cognitive dysfunction and biomarker abnormalities in severe Alzheimer's disease: A prospective single‐arm study

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION This study evaluated the efficacy of deep cervical lymphatic–venous anastomosis (dcLVA) for severe Alzheimer's disease (AD). METHODS A total of 139 severe AD patients undergoing dcLVA were enrolled, and changes in cognitive function and biomarkers were evaluated by comparing preoperative measures with postoperative outcomes over a
Xiaohong Fu, Jing Zhang, Qiuxia Xiao, Tingting Li, Qijun Li, Shaofu Zhang, Wen Zeng, Min Gong, Pan Cai, Zhaojian Deng, Xuan Zhang, Yuanjun Xin, Liping Su, Xiaohe Tian, Kaifeng Wu, Liulin Xiong   +15 more
wiley   +1 more source

Clinical Observation on Basal Ganglia Aphasia after Stroke Treated by Donepezil

康复学报, 2015
Objective:To evaluate the curative effect of donepezil on basal ganglia aphasia after stroke.Methods:A total of 37 patients with basal ganglia aphasia after stroke were randomly assigned to donepezil group (n=19) and control group (n=18).
Xi CHENG, Jinghui LAI, Zhifeng WANG, Yanling GAO, Xiaofeng CHEN, Ling LIN   +5 more
doaj  

Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals. [PDF]

, 2014
Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of ...
Cesinaro, Stefano, Esposito, Roberto, Frazzini, Valerio, Pieramico, Valentina, Sensi, Stefano L   +4 more
core   +2 more sources

β‐Asarone Attenuates Neuroinflammation of Alzheimer's Disease by Activating Autophagy and Suppressing NLRP3 Inflammasome Assembly

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu, Wanying Xu, Jinxin He, Jiahui Qian, Hui Wang, Changyu Li, Xiaojie Zhou   +6 more
wiley   +1 more source

Evaluation the effect of Donepezil on Cerebral Blood Flow Velocity in Alzheimer's Disease

مجله دانشکده پزشکی اصفهان, 2010
Background: The main cause of Alzheimer's disease (AD) is loss of cholinergic function. So, the choice strategy of therapy is to increase the level of acetylcholine (Ach) in the brain of by acetylcholinesterase inhibitors (AchEIs) such as Donepezil. This
Abbas Ghorbani, Ahmad Chitsaz, Mehdi Shishegar, Mojtaba Akbari   +3 more
doaj  

Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology [PDF]

, 2017
The British Association for Psychopharmacology coordinated a meeting of experts to review and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As before, levels of evidence were rated using accepted standards which were
Burns, A, Holmes, C, Jones, M, Jones, R, Livingston, G, McKeith, I, Mittler, P, O'Brien, JT, Passmore, P, Ritchie, C, Robinson, L, Sampson, EL, Taylor, J-P, Thomas, A   +13 more
core   +2 more sources

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Cognitive dysfunction and dementia in Parkinson's disease [PDF]

, 2004
Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder mainly characterized by degeneration of dopaminergic neurons in the substantia nigra and the ventral tegmental area, in combination with a varying loss of central noradrenergic ...
Bosboom, JL, Stoffers, D., Wolters, E.C.M.J.   +2 more
core   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source