Results 91 to 100 of about 28,065 (271)

The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents

Biomolecules & Therapeutics, 2018
A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear.
C. Shin, H. Kim, Kwang-Ho Cha, D. Won, Ji-Yun Lee, S. Jang, U. Sohn   +6 more
semanticscholar   +1 more source

Changes in the cortical GABAergic inhibitory system with ageing and ageing‐related neurodegenerative diseases

The Journal of Physiology, EarlyView.
Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley   +1 more source

Evaluation the effect of Donepezil on Cerebral Blood Flow Velocity in Alzheimer's Disease

مجله دانشکده پزشکی اصفهان, 2010
Background: The main cause of Alzheimer's disease (AD) is loss of cholinergic function. So, the choice strategy of therapy is to increase the level of acetylcholine (Ach) in the brain of by acetylcholinesterase inhibitors (AchEIs) such as Donepezil. This
Abbas Ghorbani, Ahmad Chitsaz, Mehdi Shishegar, Mojtaba Akbari   +3 more
doaj  

Donepezil Adherence, Persistence and Time to First Discontinuation in a Three-Year Follow-Up of Older People

Dementia and Geriatric Cognitive Disorders Extra, 2015
Background: Donepezil is indicated for the management of mild to moderate dementia, particularly in Alzheimer's disease. Several studies have described low adherence rates with donepezil.
Henry C. Ndukwe, Prasad S. Nishtala
doaj   +1 more source

Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s disease in Chinese patients

Clinical Interventions in Aging, 2018
Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients.
N. Zhang, M. Gordon
semanticscholar   +1 more source

Systematic review of health economic models for assessment and diagnosis of dementia

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 1, Issue 3, September 2025.
Abstract INTRODUCTION Timely diagnosis of dementia is a public health priority to enable risk modification and treatment access. This study systematically identifies and critically appraises health economic models of dementia assessment and diagnosis.
Joseph Kwon, Lisanne Schoutens, Mitchell Burden, Charlotte Colam, Sihao Zhao, Behrouz Nezafat Maldonado, Elizabeth Blundell, Anastasia Krywonos, Jingjing Jiang, Maria Karagiannidou, Christoph Jindra, Nemanja Vaci, Nia Roberts, Raphael Wittenberg, Martin Knapp, Amparo Yovanna Castro Sanchez, Emilse Roncancio‐Diaz, Michele Potashman, Robin Thompson, Ron Handels, Jane Wolstenholme, Alastair M. Gray, Filipa Landeiro, the ROADMAP Group   +23 more
wiley   +1 more source

Donepezil's Effects on Brain Functions of Patients With Alzheimer Disease: A Regional Homogeneity Study Based on Resting-State Functional Magnetic Resonance Imaging

Clinical neuropharmacology, 2019
Purpose Donepezil is known to increase cholinergic synaptic transmission in Alzheimer disease (AD), although how it affects cortical brain activity and how it consequently affects brain functions need further clarification. To investigate the therapeutic
Jianan Cheng, Hua Yang, Jiangtao Zhang
semanticscholar   +1 more source

A Short Story Changed How I Care for Persons Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
Jason Karlawish
wiley   +1 more source

Primary care management of stroke in people with dementia: Linked registry and general practice data

Australasian Journal on Ageing, Volume 44, Issue 3, September 2025.
Abstract Objectives To evaluate whether risk factor management in Australian general practices for secondary prevention of stroke differs by dementia status. Methods A retrospective study of adults with acute stroke or transient ischaemic attack (TIA) from 2014 to 2018, using de‐identified linked data (2014–2020) from the Australian Stroke Clinical ...
Muideen T. Olaiya, Joosup Kim, Christopher Pearce, Dominique A. Cadilhac, Nadine E. Andrew, Lauren Sanders, Amanda G. Thrift, Mark R. Nelson, Seana Gall, Monique F. Kilkenny   +9 more
wiley   +1 more source

Donepezil Combined with Natural Hirudin Improves the Clinical Symptoms of Patients with Mild-to-Moderate Alzheimer's Disease: A 20-Week Open-Label Pilot Study

International Journal of Medical Sciences, 2012
Aim: To evaluate the efficacy and safety of donepezil plus natural hirudin in patients with mild-to-moderate Alzheimer's Disease. Methods: In the 20-week, randomized, open-label and controlled study, 84 patients received either donepezil (5 mg/day for ...
De-qiang Li, Yu-ping Zhou, Han Yang
doaj