Results 21 to 30 of about 112,056 (332)

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

Neurobiology of Disease, 2015
The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol
S.T. Masoud, L.M. Vecchio, Y. Bergeron, M.M. Hossain, L.T. Nguyen, M.K. Bermejo, B. Kile, T.D. Sotnikova, W.B. Siesser, R.R. Gainetdinov, R.M. Wightman, M.G. Caron, J.R. Richardson, G.W. Miller, A.J. Ramsey, M. Cyr, A. Salahpour   +16 more
doaj   +1 more source

Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. [PDF]

PLoS ONE, 2014
Dopamine is a catecholamine with multiple physiological functions, playing a key role in nervous system; however its participation in reproductive processes and sperm physiology is controversial.
Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Concha   +5 more
doaj   +1 more source

Feasibility of a single-day protocol for SPECT and PET assessment of dopamine transporter availability, cardiac innervation and metabolic patterns in patients with movement disorders. [PDF]

Eur J Nucl Med Mol Imaging
Scheifele M, Gnörich J, Schröder E, Kunte SC, Ells Z, Hagen J, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Franzmeier N, Fischer M, Levin J, Höglinger GU, Werner RA, Brendel M.   +15 more
europepmc   +3 more sources

Mice in ecstasy : advanced animal models in the study of MDMA [PDF]

, 2010
The party drug 3,4-methylenedioxymethamphetamine -better known as MDMA or ecstasy- has numerous effects on the human body, characterized by a rush of energy, euphoria and empathy.
Stove, Christophe, De Letter, Els, Piette, Michel, Lambert, Willy   +3 more
core   +2 more sources

Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

PLoS ONE, 2013
Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals.
Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada   +8 more
doaj   +1 more source

Effect of palmitoylation on the dimer formation of the human dopamine transporter

Scientific Reports, 2021
The human dopamine transporter (hDAT) is one in three members of the monoamine transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the synaptic cleft through dopamine reuptake into the presynaptic neuron; thereby ...
Talia Zeppelin, Kasper B. Pedersen, Nils A. Berglund, Xavier Periole, Birgit Schiøtt   +4 more
doaj   +1 more source

The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice

Biomolecules, 2022
Previous studies have shown that atypical dopamine-transporter-inhibitors such as modafinil and its analogues modify behavioral and cognitive functions in rodents.
Karl Ebner, Simone B. Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J. Leban, Nicolas Singewald, Mario Engelmann, Gert Lubec   +9 more
doaj   +1 more source

Epigenetic regulation-mediated disorders in dopamine transporter endocytosis: A novel mechanism for the pathogenesis of Parkinson's disease. [PDF]

Theranostics
Liang Z, Liu W, Cao M, Cui J, Lan J, Ding Y, Zhang T, Yang Z.   +7 more
europepmc   +3 more sources

In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999. [PDF]

, 2013
INTRODUCTION: We examined whether [(18)F]LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat ...
Chalon, Sylvie, Deloye, Jean-Bernard, Galineau, Laurant, Garreau, Lucette, Guilloteau, Denis, Sérrière, Sophie, Tauber, Clovis, Vercouillie, Johnny   +7 more
core   +1 more source

Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking [PDF]

, 2013
Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood.
Baker, David A., Ebben, Amanda L., Gasser, Paul J., Graf, Evan N., Hill, Jonathan E., Mantsch, John R., McReynolds, Jayme R., Robble, Mykel A., Vranjkovic, Oliver, Wheeler, Daniel S., Wheeler, Robert A.   +10 more
core   +2 more sources