Results 231 to 240 of about 51,709 (292)

Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats

European Journal of Pharmacology, 1995
In vivo central effects of some dopamine uptake inhibitors were evaluated in both brain microdialysis and behavioural studies in rats, and compared with their in vitro affinities to dopamine uptake sites. IC50 values of GBR12909 (1-[2- bis(4-fluorophenyl)methoxy]ethyl]-4-(3- phenylpropyl)piperazine), diclofensine, mazindol, amfonelic acid and ...
N, Nakachi   +5 more
openaire   +4 more sources

In vivo characterization of locally applied dopamine uptake inhibitors by striatal microdialysis

Synapse, 1990
AbstractIn vivo brain microdialysis was used to characterize the effects of some dopamine uptake inhibitors on the extracellular concentrations of dopamine (DA) and its metabolitesdihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striata of awake, freely moving rats.
G G, Nomikos   +3 more
openaire   +4 more sources

Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors

European Journal of Pharmacology, 1994
Binding to the dopamine transporter and inhibiting dopamine reuptake are considered important factors in regulating behavioral effects of cocaine. One prominent behavioral effect of cocaine and other dopamine uptake inhibitors is the stimulation of locomotor activity.
S, Izenwasser   +4 more
openaire   +4 more sources

Dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons

Brain Research, 1990
A single large dose (100 mg/kg, s.c.) of methamphetamine (MA) is known to exert neurotoxic effects on dopaminergic neurons. The potency at which a series of dopamine (DA) uptake inhibitors blocked MA-induced neostriatal depletions (amfonelic acid (AFA) much greater than mazindol (MAZ) greater than or equal to bupropion (BUP) greater than benztropine ...
G J, Marek, G, Vosmer, L S, Seiden
openaire   +4 more sources

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