Results 241 to 250 of about 51,709 (292)

In vivo neurochemical profile of dopamine uptake inhibitors and releasers in rat caudate-putamen

European Journal of Pharmacology, 1989
The in vivo neurochemical profile of recently synthesized dopamine (DA) uptake inhibitors (Lu 19-005, Lu 17-133 and GBR 12.921) is described. The antidepressant, nomifensine, as well as another typical DA uptake inhibitor, methylphenidate, was also tested with the microdialysis technique. Most of the new DA uptake inhibitors induced a gradual dose- and
Y L, Hurd, U, Ungerstedt
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Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test

European Journal of Pharmacology, 2004
The effects of dopamine re-uptake inhibitors, bupropion and nomifensine on immobility in the forced swimming test were studied in mice. Bupropion and nomifensine reduced immobility time dose-dependently. Both drugs significantly displayed anti-immobility effects at doses without altering locomotor activity.
Jun, Yamada, Yumi, Sugimoto, Shizuo, Yamada   +2 more
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Differential time‐course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors

Synapse, 2001
AbstractUsing real‐time voltammetry, we compared the effects of cocaine (1.0, 3.0, or 10 μM), WIN 35428 (0.1, 0.5, or 2.0 μM), and nomifensine (0.2, 1.0, or 5.0 μM) on electrically evoked dopamine release and uptake in the rat accumbens slice.
T H, Lee, R, Balu, C, Davidson, E H, Ellinwood   +3 more
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Place conditioning with cocaine and the dopamine uptake inhibitor GBR12783

NeuroReport, 1996
The rewarding and locomotor effects of the specific dopamine uptake inhibitor GBR12783 (2.5-20 mg kg-1, i.p.) were compared with those of cocaine. For both drugs, all doses produced a conditioned place preference (CPP), even the dose of 2.5 mg kg-1, which did not modify the locomotor activity.
G, Le Pen, D, Duterte-Boucher, J, Costentin   +2 more
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Interactions of Cocaine with Dopamine Uptake Inhibitors or Dopamine Releasers in Rats Discriminating Cocaine

The Journal of Pharmacology and Experimental Therapeutics, 2006
Several dopamine (DA) indirect agonists have been proposed as potential medications for treating cocaine abuse. The objective of the present study was to quantify the interactions among cocaine and DA uptake inhibitors or DA releasers to better understand how these drugs may be working when administered in combination.
Su-Min, Li, Bettye L, Campbell, Jonathan L, Katz   +2 more
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Conformationally rigid dopamine analogues as inhibitors of dopamine and 5-hydroxytryptamine uptake by synaptosomes

Journal of Neural Transmission, 1987
Derivatives of trans-decalin with a dopamine moiety incorporated in different conformations were studied as inhibitors of dopamine and 5-HT uptake in rat brain synaptosomes. In three derivatives the relation of the catechol ring and the amino function was gauche, in one isomer it was anti.
J, Tuomisto, L, Tuomisto
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Sodium independence of the binding of [3H]GBR 12783 and other dopamine uptake inhibitors to the dopamine uptake complex

Neuroscience Letters, 1987
When Na+ was the only cation present in the incubation medium used for the determination of the specific binding of [3H]GBR 12783 in rat striatal membranes, the Na+-dependence between 10 and 210 mM Na+ was not observed. In media with low (10 mM) or high (130 mM) Na+ concentration, mazindol and nomifensine competed with [3H]GBR 12783 for its specific ...
S, Benmansour, J J, Bonnet, P, Protais, J, Costentin   +3 more
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Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors.

The Journal of Pharmacology and Experimental Therapeutics, 1991
The effect of dopamine (DA) and serotonin (5-HT) uptake inhibitors on 3,4-methylenedioxymethamphetamine (MDMA)-induced increase in DA efflux was studied using in vivo microdialysis. MDMA was infused directly into the anterolateral striatum via the dialysis probe.
J F, Nash, J, Brodkin
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Cross-sensitization between cocaine and GBR 12909, a dopamine uptake inhibitor

Brain Research Bulletin, 1991
In the present experiment, rats which had received repeated injections of 20 mg/kg GBR 12909, a selective dopamine uptake inhibitor, were subjected to challenge doses of GBR 12909 and cocaine which were near or below the threshold for locomotor activation in drug-naive animals.
B A, Baldo, A E, Kelley
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Cocaine cross-sensitization to dopamine uptake inhibitors: Unique effects of GBR12909

Pharmacology Biochemistry and Behavior, 1996
Repeated administration of cocaine will cross-sensitize the locomotor response to a variety of psychomotor stimulants. The ability of cocaine to cross-sensitize the locomotor effects of other psychomotor stimulants provides information relevant to the pharmacological mechanisms underlying the sensitization process. The purpose of the current experiment
G I, Elmer, A, Brockington, D A, Gorelick, F I, Carrol, K C, Rice, D, Matecka, S R, Goldberg, R B, Rothman   +7 more
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