Results 261 to 270 of about 51,709 (292)

Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter

2008
The dopamine transporter (DAT) has been a primary target for cocaine abuse/addiction medicationdiscovery. However predicted addiction liability and limited clinical evaluation has provided a formidablechallenge for development of these agents for human use. The unique and atypical pharmacological profileof the benztropine (BZT) class of dopamine uptake
Amy Hauck Newman, Jonathan L. Katz
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Fluoxetine at anorectic doses does not have properties of a dopamine uptake inhibitor

Journal of Neural Transmission, 1994
Although fluoxetine is a highly selective inhibitor of serotonin uptake in vitro and in vivo, some investigators have suggested that dopamine uptake inhibition may contribute to anorectic actions of fluoxetine. The present experiments were done to determine fluoxetine's effects in some animal protocols in which dopamine uptake inhibitors have ...
R W, Fuller, S K, Hemrick-Luecke, H D, Snoddy   +2 more
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Effects of dopamine uptake inhibitor MRZ-9547 in animal models of Parkinson’s disease

Journal of Neural Transmission, 2014
MRZ-9547 (d-(2-(2-oxo-4(R)-phenylpyrrolidin-1-yl)-acetamide) is a drug acting at the dopamine transporter (DAT). In the present study, effects of MRZ-9547 alone and in combination with L-3,4-dihydroxyphenylalanine (L-DOPA) were investigated in rodent models predictive for efficacy in Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID). In rats
Andrzej, Dekundy, Flora, Mela, Martine, Hofmann, Wojciech, Danysz   +3 more
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Synthesis of 3-arylecgonine analogs as inhibitors of cocaine binding and dopamine uptake

Journal of Medicinal Chemistry, 1990
3-Arylecgonine analogues were synthesized and characterized by 1H and 13C NMR, IR, and MS. The compounds were synthesized as racemates from cycloheptatriene-7-carboxylic acid or enantiomerically from (-)-cocaine. These analogues were tested for their ability to inhibit [3H]cocaine binding to bovine striatal tissue and to inhibit [3H]dopamine uptake ...
R H, Kline, J, Wright, K M, Fox, M E, Eldefrawi   +3 more
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Although Chemically Related to Amineptine, the Antidepressant Tianeptine Is Not a Dopamine Uptake Inhibitor

Pharmacology Biochemistry and Behavior, 1999
We investigated whether the antidepressant tianeptine shares the dopamine uptake inhibitory properties of the chemically related antidepressant amineptine. Tianeptine dose dependently (5, 10, 20, 40 mg/kg IP) increased locomotor activity in mice. This stimulant effect (20 mg/kg IP) was dose dependently prevented not only by the D1 dopamine receptor ...
Vaugeois, J. M., Corera, a T, Deslandes, A, Costentin, J   +3 more
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Analysis of the activation of dopamine metabolism by a serotonin uptake inhibitor

European Journal of Pharmacology, 1979
The potentiation of the effect of haloperidol on rat striatal homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) by a serotonin (5-HT) uptake inhibitor, CGP 6085 A, has been further investigated. The evidence that this effect of CGP 6085 A is related to its 5-HT uptake inhibitory properties is discussed. The potentiation was antagonized
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(−)-3β-Substituted Ecgonine Methyl Esters as Inhibitors for Cocaine Binding and Dopamine Uptake

Journal of Medicinal Chemistry, 1998
Ten 3 beta-ecgonine analogues were synthesized and characterized by 1H and 13C NMR, MS, and elemental analysis. The compounds were synthesized as (-)-stereoisomers from (-)-cocaine. These compounds were assessed for their ability to inhibit [3H]cocaine binding to rat striatal tissue and to inhibit [3H]DA uptake into rat striatal synaptosomes.
S F, Lieske, B, Yang, M E, Eldefrawi, A D, MacKerell, J, Wright   +4 more
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Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

European Journal of Pharmacology, 1985
Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP.
E, Melamed, J, Rosenthal, O, Cohen, M, Globus, A, Uzzan   +4 more
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Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier

European Journal of Pharmacology, 1994
We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum.
C, Héron, J, Costentin, J J, Bonnet
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Effects of dopamine uptake inhibitors on schedule-controlled behavior in the squirrel monkey

Psychopharmacology, 1982
Squirrel monkeys responded under a multiple fixed-interval (FI) fixed-ratio (FR) schedule of stimulus-shock termination. Benztropine mesylate (0.03-1.7 mg/kg), bupropion HCl (0.3-5.6 mg/kg), mazindol (0.01-0.3 mg/kg), and nomifensine maleate (0.1-1.0 mg/kg) markedly increased responding under the FI schedule, but not under the FR schedule. Mazindol was
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