Results 11 to 20 of about 78,023 (273)

Elastic dosage compensation by X-chromosome upregulation [PDF]

Nature Communications, 2022
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius   +8 more
doaj   +2 more sources

Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]

Nature Communications
In mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei, Barry Kesner, Uri Weissbein, Peera Wasserzug-Pash, Priyojit Das, Jeannie T. Lee   +5 more
doaj   +2 more sources

Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows. [PDF]

PLoS Genetics, 2023
The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán, Justin Merondun, Ulrich Knief, Jochen B W Wolf   +3 more
doaj   +2 more sources

A Synthetic Sponge System Against miRNAs of the miR-17/92 Cluster Targets Transcriptional MYC Dosage Compensation in Aneuploid Cancer [PDF]

Cells
Background: Genomic instability, a hallmark of cancer, leads to copy number variations disrupting gene dosage balance and contributing to tumor progression.
Diana M. Bravo-Estupiñan, Carsten Geiß, Jorge L. Arias-Arias, Mariela Montaño-Samaniego, Ricardo Chinchilla-Monge, Christian Marín-Müller, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Miguel Ibáñez-Hernández, Rodrigo A Mora-Rodríguez   +9 more
doaj   +2 more sources

Cell-Type Specific Variation in X-Chromosome Dosage Compensation in Drosophila. [PDF]

MicroPubl Biol
Pal S, Oliver B, Przytycka TM.
europepmc   +4 more sources

Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes [PDF]

BMC Biology, 2007
Background The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and between sex chromosomes and autosomes.
Kultima Kim, Dencker Lennart, Brunström Björn, Hultin-Rosenberg Lina, Ellegren Hans, Scholz Birger   +5 more
doaj   +2 more sources

RNA stability controlled by m⁶A methylation contributes to X-to-autosome dosage compensation in mammals. [PDF]

Nat Struct Mol Biol, 2023
Rücklé C, Körtel N, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI, König J.   +16 more
europepmc   +3 more sources

Modulation of transcription burst amplitude underpins dosage compensation in the Drosophila embryo

Cell Reports, 2023
Summary: Dosage compensation, the balancing of X-linked gene expression between sexes and to the autosomes, is critical to an organism’s fitness and survival. In Drosophila, dosage compensation involves hypertranscription of the male X chromosome.
Lauren Forbes Beadle, Hongpeng Zhou, Magnus Rattray, Hilary L. Ashe   +3 more
doaj   +2 more sources

Genome report: Genome of the Amazon guppy (Poecilia bifurca) reveals conservation of sex chromosomes and dosage compensation. [PDF]

G3 (Bethesda)
Fong LJM, Johnson BD, Darolti I, Sandkam BA, Mank JE.   +4 more
europepmc   +3 more sources

HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation. [PDF]

Genome Biol Evol
Charlesworth B, Charlesworth D.
europepmc   +3 more sources