When Down Is Up: Heterochromatin, Nuclear Organization and X Upregulation
Cells, 2021 Organisms with highly differentiated sex chromosomes face an imbalance in X-linked gene dosage. Male Drosophila solve this problem by increasing expression from virtually every gene on their single X chromosome, a process known as dosage compensation ...
Reem Makki, Victoria H. Meller
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Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1. [PDF]
PLoS Genetics, 2009 Dosage compensation ensures similar levels of X-linked gene products in males (XY or XO) and females (XX), despite their different numbers of X chromosomes.
Emily L Petty +4 more
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Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. [PDF]
PLoS Genetics, 2014 Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and ...
Susan E Lott +4 more
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No evidence for a global male-specific lethal complex-mediated dosage compensation contribution to the demasculinization of the Drosophila melanogaster X chromosome. [PDF]
PLoS ONE, 2014 In Drosophila melanogaster males, the expression of X-linked genes is regulated by mechanisms that operate on a chromosomal scale. One such mechanism, male-specific lethal complex-dependent X-linked dosage compensation, is thought to broadly enhance the ...
Steven P Vensko, Eric A Stone
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Scientific Reports, 2021 In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance ...
Ana Luíza Cidral +3 more
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Frontiers in Genetics, 2021 How pleiotropy influences evolution of protein sequence remains unclear. The male-specific lethal (MSL) complex in Drosophila mediates dosage compensation by 2-fold upregulation of the X chromosome in males.
Aimei Dai +4 more
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Partial dosage compensation in Strepsiptera, a sister group of beetles. [PDF]
, 2015 Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Bachtrog, Doris, Mahajan, Shivani
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Incomplete sex chromosome dosage compensation in the Indian meal moth, Plodia interpunctella, based on de novo transcriptome assembly. [PDF]
, 2016 Journal ArticleResearch Support, Non-U.S. Gov'tMales and females experience differences in gene dose for loci in the nonrecombining region of heteromorphic sex chromosomes. If not compensated, this leads to expression imbalances, with the homogametic sex
Harrison, PW, Mank, JE, Wedell, Nina
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Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development
Cell Reports, 2019 Summary: Dosage compensation, which corrects for the imbalance in X-linked gene expression between XX females and XY males, represents a model for how genes are targeted for coordinated regulation.
Leila Elizabeth Rieder +2 more
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SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila. [PDF]
PLoS Genetics, 2008 In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome.
Anne Spierer +3 more
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