Results 41 to 50 of about 72,919 (193)
Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels. [PDF]
PLoS ONE, 2011 Dosage compensation is a specialized form of gene regulation that balances sex-chromosome linked gene expression between the sexes. In C. elegans, dosage compensation is achieved by the activity of the dosage compensation complex (DCC).
Emily Petty +2 more
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Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]
, 2015 The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R +4 more
core +1 more source
Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. [PDF]
, 2007 Many genes can be deleted with little phenotypic consequences. By what mechanism and to what extent the presence of duplicate genes in the genome contributes to this robustness against deletions has been the subject of considerable interest.
Collins, Sean R +4 more
core +4 more sources
Dosage compensation can buffer copy-number variation in wild yeast
eLife, 2015 Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy,
James Hose +5 more
doaj +1 more source
Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos, and Somatic Tissues [PDF]
, 2019 Dosage compensation of the mammalian X chromosome (X) was proposed by Susumu Ohno as a mechanism wherein the inactivation of one X in females would lead to doubling the expression of the other.
Jiang, Zongliang
core +2 more sources
PLoS Genetics, 2020 Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Koji Ishikawa +2 more
doaj +1 more source
Cells, 2020 Chromosome-specific regulatory mechanisms provide a model to understand the coordinated regulation of genes on entire chromosomes or on larger genomic regions. In fruit flies, two chromosome-wide systems have been characterized: The male-specific lethal (
Samaneh Ekhteraei-Tousi +2 more
doaj +1 more source
Male-killing bacteria in insects: mechanisms, incidence and implications [PDF]
, 2000 Bacteria that are vertically transmitted through female hosts and kill male hosts that inherit them were first recorded in insects during the 1950s. Recent studies have shown these "male-killers" to be diverse and have led to a reappraisal of the biology
Hurst, GDD, Jiggins, FM
core +2 more sources
DOSAGE COMPENSATION: REGULATION OF SEX CHROMOSOME GENE EXPRESSION
Вавиловский журнал генетики и селекции, 2014 Dosage compensation is observed in various taxa of organisms with heteromorphic sex chromosomes. Dosage compensation mechanisms are thought to have arisen to eliminate differences in gene dosage between sexes that appeared in the course of sex chromosome
E. V. Dementyeva
doaj
Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
Nature Communications, 2019 In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C ...
Koustav Pal +9 more
doaj +1 more source