A General Mechanism for Network-Dosage Compensation in Gene Circuits [PDF]
, 2010 Coping with variations in network dosage is crucial for maintaining optimal function in gene networks. We explored how network structure facilitates network-level dosage compensation.
Acar, Murat +4 more
core +2 more sources
Masc‐induced dosage compensation in silkworm cultured cells
FEBS Open Bio, 2019 The Masculinizer (Masc) gene encodes a CCCH‐tandem zinc finger protein that controls both masculinization and dosage compensation in the silkworm Bombyx mori.
Susumu Katsuma +4 more
doaj +1 more source
Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]
, 2019 Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris +2 more
core +1 more source
Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]
, 2015 The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R +4 more
core +1 more source
Optimization of PET protocol and interrater reliability of 18F-PSMA-11 imaging of prostate cancer [PDF]
, 2020 Background Several scan parameters for PET imaging with F-18-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide administration on lesion ...
Achten, Eric +7 more
core +2 more sources
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
iScience, 2021 Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón +16 more
doaj +1 more source
De novo transcriptome assembly reveals sex-specific selection acting on evolving neo-sex chromosomes in Drosophila miranda. [PDF]
, 2014 BackgroundThe Drosophila miranda neo-sex chromosome system is a useful resource for studying recently evolved sex chromosomes. However, the neo-Y genomic assembly is fragmented due to the accumulation of repetitive sequence.
Bachtrog, Doris, Kaiser, Vera B
core +2 more sources
The C. elegans dosage compensation complex mediates interphase X chromosome compaction [PDF]
, 2014 Background Dosage compensation is a specialized gene regulatory mechanism which equalizes X-linked gene expression between sexes. In Caenorhabditis elegans, dosage compensation is achieved by the activity of the dosage compensation ...
Csankovszki, Györgyi +2 more
core +1 more source
Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]
PLoS Genetics, 2008 X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston +5 more
doaj +1 more source
, 2020 X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L. +4 more
core +1 more source