Results 1 to 10 of about 255,580 (244)

A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA SignalingSummaryWhat You Need to Know [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Recent evidence suggests that endogenously derived double-stranded RNA (dsRNA) impacts multiple cellular processes, although its role in epithelial injury remains understudied.
Angela M. Halstead, Chinye Nwokolo, Stella Hoft, Jinsheng Yu, Lifei Zhu, Brendan Tuley, Nancy Vargas, RuiRui Liu, Francisco Ramirez Victorino, Simrin Phatak, Wandy Beatty, Chun-Kan Chen, Richard DiPaolo, Paul Cliften, Tarin M. Bigley, José B. Sáenz   +15 more
doaj   +2 more sources

Double stranded RNA sensing is silenced during early embryonic development [PDF]

Nature Communications
The type I interferon response is inactive during early mammalian development and becomes functional only after gastrulation. As a result, the totipotent and pluripotent embryonic stages remain susceptible to pathogens, including viruses.
Jeroen Witteveldt, Zicong Liu, Ana Ariza-Cosano, Christian Ramirez, Jessica L. Walters, Pilar G. Marchante, Lars Maas, Elias T. Friman, Alasdair Ivens, Toma Tebaldi, Sara R. Heras, Hendrik Marks, Sara Macias   +12 more
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Spontaneous base flipping helps drive Nsp15’s preferences in double stranded RNA substrates [PDF]

Nature Communications
Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3′ of uridine (U).
Zoe M. Wright, Kevin John Butay, Juno M. Krahn, Isha M. Wilson, Scott A. Gabel, Eugene F. DeRose, Israa S. Hissein, Jason G. Williams, Mario J. Borgnia, Meredith N. Frazier, Geoffrey A. Mueller, Robin E. Stanley   +11 more
doaj   +2 more sources

Influenza A virus circumvents the innate immune response through the sequestration of double-stranded RNA. [PDF]

J Virol
Nakano M, Miyamoto S, Ohnishi C, Nogami C, Hirose N, Fujita-Fujiharu Y, Muramoto Y, Noda T.   +7 more
europepmc   +3 more sources

Structural basis of double-stranded RNA recognition by the J2 monoclonal antibody. [PDF]

Nat Commun
Bou-Nader C, Juma KM, Bothra A, Brasington AJ, Ghirlando R, Suzuki M, Garboczi DN, Leppla SH, Zhang J.   +8 more
europepmc   +3 more sources

Endogenous Double-Stranded RNA

Non-Coding RNA, 2021
The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and activation of repetitive elements in the genome. The transcription of endogenous retroviruses as well as long and short interspersed elements is not only essential ...
Shaymaa Sadeq, Surar Al-Hashimi, Carmen M. Cusack, Andreas Werner   +3 more
doaj   +1 more source

Breeding of virus-resistant transgenic sugarcane by the integration of the Pac1 gene

Frontiers in Sustainable Food Systems, 2022
Various RNA viral diseases on sugarcane result in yield loss and decreased sugar content. Breeding new varieties with virus resistance is the main goal of the sugarcane breeding program.
Wenzhi Wang, Wenzhi Wang, Jungang Wang, Xiaoyan Feng, Llinbo Shen, Cuilian Feng, Tingting Zhao, Hong Xiao, Shifang Li, Shuzhen Zhang   +9 more
doaj   +1 more source

RNA Helicase A Regulates the Replication of RNA Viruses

Viruses, 2021
The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell.
Rui-Zhu Shi, Yuan-Qing Pan, Li Xing
doaj   +1 more source

BmCPV-Derived Circular DNA vcDNA-S7 Mediated by Bombyx mori Reverse Transcriptase (RT) Regulates BmCPV Infection

Frontiers in Immunology, 2022
Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu, Jun Pan, Xinyu Tong, Qunnan Qiu, Xing Zhang, Yaxin Zhang, Sufei Sun, Yongjie Feng, Renyu Xue, Guangli Cao, Xiaolong Hu, Xiaolong Hu, Chengliang Gong, Chengliang Gong   +13 more
doaj   +1 more source

Characteristic of the active substance of the Saccharomyces cerevisiae preparation having radioprotective properties

Вавиловский журнал генетики и селекции, 2020
The paper describes some biological features of the radioprotective effect of double-stranded RNA preparation. It was found that yeast RNA preparation has a prolonged radioprotective effect after irradiation by a lethal dose of 9.4 Gy.
G. S. Ritter, V. P. Nikolin, N. A. Popova, A. S. Proskurina, P. E. Kisaretova, O. S. Taranov, T. D. Dubatolova, E. V. Dolgova, E. A. Potter, S. S. Kirikovich, Y. R. Efremov, S. I. Bayborodin, M. V. Romanenko, M. I. Meschaninova, A. G. Venyaminova, N. A. Kolchanov, S. S. Bogachev   +16 more
doaj   +1 more source