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Endogenous Double-Stranded RNA [PDF]
Non-Coding RNA, 2021 The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and activation of repetitive elements in the genome. The transcription of endogenous retroviruses as well as long and short interspersed elements is not only essential ...
Shaymaa Sadeq +3 more
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Neurodegeneration, Heterochromatin, and Double-Stranded RNA [PDF]
Journal of Experimental Neuroscience, 2019 Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear.
Tassa K Saldi +3 more
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A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA SignalingSummaryWhat You Need to Know [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Recent evidence suggests that endogenously derived double-stranded RNA (dsRNA) impacts multiple cellular processes, although its role in epithelial injury remains understudied.
Angela M. Halstead +15 more
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Double stranded RNA sensing is silenced during early embryonic development [PDF]
Nature CommunicationsThe type I interferon response is inactive during early mammalian development and becomes functional only after gastrulation. As a result, the totipotent and pluripotent embryonic stages remain susceptible to pathogens, including viruses.
Jeroen Witteveldt +12 more
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Cell Reports, 2014 Double-stranded RNA (dsRNA) can function as genetic information and may have served as genomic material before the existence of DNA-based life. By developing a method to purify dsRNA, we have investigated the diversity of dsRNA in microbial populations ...
Carolyn J. Decker, Roy Parker
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Spontaneous base flipping helps drive Nsp15’s preferences in double stranded RNA substrates [PDF]
Nature CommunicationsCoronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3′ of uridine (U).
Zoe M. Wright +11 more
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Breeding of virus-resistant transgenic sugarcane by the integration of the Pac1 gene
Frontiers in Sustainable Food Systems, 2022 Various RNA viral diseases on sugarcane result in yield loss and decreased sugar content. Breeding new varieties with virus resistance is the main goal of the sugarcane breeding program.
Wenzhi Wang +9 more
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RNA Helicase A Regulates the Replication of RNA Viruses
Viruses, 2021 The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell.
Rui-Zhu Shi, Yuan-Qing Pan, Li Xing
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Overstretching Double-Stranded RNA, Double-Stranded DNA, and RNA-DNA Duplexes [PDF]
Biophysical Journal, 2019 Using single-molecule force measurements, we compare the overstretching transition of the four types of duplexes composed of DNA or RNA strands. Three of the four extremities of each double helix are attached to two microscopic beads, and a stretching force is applied with a dual-beam optical trapping interferometer.
Melkonyan, Lena +3 more
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Frontiers in Immunology, 2022 Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu +13 more
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