Results 201 to 210 of about 254,386 (241)

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Correction: Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge. [PDF]

PLoS One
Rimmer C, Hetelekides S, Eliseeva SI, Georas SN, Veazey JM.   +4 more
europepmc   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Induction of apoptosis by double-stranded RNA was present in the last common ancestor of cnidarian and bilaterian animals. [PDF]

PLoS Pathog
Kozlovski I, Jaimes-Becerra A, Sharoni T, Lewandowska M, Karmi O, Moran Y.   +5 more
europepmc   +1 more source

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Control of two insect pests by expression of a mismatch corrected double-stranded RNA in plants. [PDF]

Plant Biotechnol J
Dong Y, Zhang Q, Mao Y, Wu M, Wang Z, Chang L, Zhang J.   +6 more
europepmc   +1 more source

Significant Variations in Double-Stranded RNA Levels in Cultured Skin Cells. [PDF]

Cells
Sadeq S, Chitcharoen S, Al-Hashimi S, Rattanaburi S, Casement J, Werner A.   +5 more
europepmc   +1 more source

LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes. [PDF]

Cell Death Dis
Keller J, Danis J, Krehl I, Girousi E, Satoh TK, Meier-Schiesser B, Kemény L, Széll M, Wong WW, Pascolo S, French LE, Kündig TM, Mellett M.   +12 more
europepmc   +1 more source

Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding. [PDF]

Elife
Parvez F, Sangpal D, Paithankar H, Amin Z, Chugh J.   +4 more
europepmc   +1 more source

Double-stranded RNA induces antiviral transcriptional response through the Dicer-2/Ampk/FoxO axis in an arthropod. [PDF]

Proc Natl Acad Sci U S A
Gao J, Liu CF, Liu PP, Wang XW.
europepmc   +1 more source