Results 181 to 190 of about 16,723 (215)

Posttranscriptional Crossregulation between Drosha and DGCR8 [PDF]

Cell, 2009
The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these ...
Jinju Han, Jakob Skou Pedersen, S Chul Kwon   +2 more
exaly   +6 more sources

Structural Basis for pri-miRNA Recognition by Drosha [PDF]

Molecular Cell, 2020
A commencing and critical step in miRNA biogenesis involves processing of pri-miRNAs in the nucleus by Microprocessor. An important, but not completely understood, question is how Drosha, the catalytic subunit of Microprocessor, binds pri-miRNAs and correctly specifies cleavage sites.
Jia Wang, Chao-Pei Liu, Hong-Wei Wang
exaly   +3 more sources

Dysregulated Expression of Dicer and Drosha in Breast Cancer

Pathology and Oncology Research, 2011
Large-scale profiling approaches have revealed global down-regulation of microRNAs (miRNAs) in several human cancer types including breast cancer. Altered expression of Dicer and Drosha, two key enzymes in the miRNA maturation, is believed to be one of the most important mechanisms.
Min Yan, Yi Wan, Zhen-Zhen Liu
exaly   +3 more sources

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Drosha cuts the tethers of myelopoiesis

Nature Immunology, 2015
The RNA endonuclease Drosha is required for myelopoiesis by its direct cleavage of stem-loop structures in mRNAs encoding Myl9 and Todr1.
Annemarthe G van der Veen, Pierre V Maillard, Caetano Reis e Sousa   +2 more
openaire   +3 more sources

Impaired expression of Drosha in breast cancer

Breast Disease, 2017
BACKGROUND: Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer. OBJECTIVE: To evaluate the expression pattern of Drosha in patients with breast cancer.
Ali Akbar, Poursadegh Zonouzi, Mohammad, Shekari, Azim, Nejatizadeh, Samira, Shakerizadeh, Hedieh, Fardmanesh, Ahmad, Poursadegh Zonouzi, Mohammad, Rahmati-Yamchi, Majid, Tozihi   +7 more
openaire   +2 more sources

Dicer and Drosha expression in patients with nephrotic syndrome

BioFactors, 2020
AbstractPodocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria.
Seyyedeh Mina Hejazian, Yalda Rahbar Saadat, Zahra Bahmanpour, Seyed Mahdi Hosseiniyan Khatibi, Mohammadreza Ardalan, Sepideh Zununi Vahed   +5 more
openaire   +2 more sources

Characterization of shrimp Drosha in virus infection

Fish & Shellfish Immunology, 2012
RNA interference (RNAi) mediated by microRNA (miRNA) is an evolutionarily conserved mechanism of posttranscriptional gene regulation in all eukaryotes, involving in natural antiviral immunity. The RNAase III Drosha is a key component for miRNA maturation. To date, however, the roles of Drosha in virus infection remain to be addressed.
Tianzhi, Huang, Dandan, Xu, Xiaobo, Zhang   +2 more
openaire   +2 more sources

Review: Non-canonical role of Drosha ribonuclease III

International Journal of Biological Macromolecules, 2023
The typical function of Drosha is participating in cleaving pri-miRNA, the initial step of miRNA biogenesis, in the nucleus. Since Drosha has a double-stranded RNA-binding domain and two RNase III domains, when it binds and/or cleaves other RNA species other than pri-miRNA, Drosha is able to induce a variety of novel biological effects.
Jin Tang
exaly   +3 more sources