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A novel cardioprotective function for DRP1 inhibition
Nature Reviews Cardiology, 2021A new study identifies a small-molecule inhibitor of a mitochondrial fission protein that reduces PCSK9 secretion and atherosclerotic plaque formation.
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Abstract P3178: Gja1-20k Is Downstream Of Drp1 And Can Rescue Drp1 Suppression In Mouse Heart
Circulation Research, 2023Dynamin-Related Protein 1 (DRP1) is a major mediator of mitochondrial fission and its mutation results with hyper-fused mitochondria and, in mice, a dilated cardiomyopathy. GJA1-20k is the most abundant N-terminus truncated isoform of Connexin 43 (Cx43) formed by internal translation and was originally identified as a trafficking subunit of Cx43.
Jennifer Hunter +4 more
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Inhibition of Drp1 provides neuroprotection in vitro and in vivo [PDF]
Cell Death and Differentiation, 2012 Impaired regulation of mitochondrial dynamics, which shifts the balance towards fission, is associated with neuronal death in age-related neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. A role for mitochondrial dynamics in acute brain injury, however, has not been elucidated to date.
Carsten Culmsee
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Recruitment of Drp1 in Mitochondrial Fission
The FASEB Journal, 2017Intracellular membranes are dynamically shaped by proteins including fission and fusion events important for vesicular transport, organelle trafficking, and cellular homeostasis. Yet how proteins interact with membranes to control these events is largely unknown.
John M Egner +3 more
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Drp1-dependent mitochondrial fission in cardiovascular disease
Acta Pharmacologica Sinica, 2020Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy ...
Jia-Yu, Jin +4 more
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DRP1 Association in Inflammation and Metastasis: A Review
Current Drug Targets: In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on aging, human health, and other advanced findings in metabolic functions. The latest finding shows that metabolic interventions are a leading cause of several diseases, which has sparked interest in finding new therapeutic ...
Parmar Keshri Nandan +2 more
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DRP1 in reproduction and reproductive aging
Biology of ReproductionAbstract Dynamin-related protein 1 (DRP1) is a central regulator of mitochondrial fission and plays a critical role in maintaining mitochondrial function, distribution, and turnover in reproductive cells. Mitochondrial integrity is essential for oocyte quality, folliculogenesis, fertilization, embryonic development, and ultimately ...
Cheng-Rung Huang +4 more
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Design and Synthesis of Drp1 Inhibitors
2022A thesis submitted in total fulfilment of the requirement for the degree of Master of Science to the Department of Chemistry and Physics, School of Molecular Science, College of Science, Health and Engineering, La Trobe University, Victoria, Australia.
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The impact of DRP1 on myocardial fibrosis in the obese minipig
European Journal of Clinical Investigation, 2020AbstractBackgroundThe heart is a highly oxidative tissue, thus mitochondria play a major role in maintaining optimal cardiac function. Our previous study established a dietary‐induced obese minipig with cardiac fibrosis. The aim of this study was to elucidate the role of mitochondrial dynamics in cardiac fibrosis of obese minipigs.DesignFour‐month‐old ...
Ching‐Yi Chen +4 more
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Drp1 in Ischemic Neuronal Death: An Unusual Suspect
Current Medicinal Chemistry, 2014Mitochondria play a crucial role in multitude of cellular processes including energy production, calcium signaling, and apoptosis. This remarkable organelle constantly undergoes a complex cycle of fusion and fission, a crucial quality control system for maintaining homeostasis of the cell.
H, Pradeep, B, Sharma, G K, Rajanikant
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