Results 251 to 260 of about 29,949 (269)

Mechanisms of Drp1 Recruitment to Mitochondria

2017
Dynamin-related protein 1 (Drp1) is a GTPase of the dynamin superfamily that catalyzes mitochondrial fission in the cell. Cytosolic Drp1 is recruited to mitochondria by receptors anchored to the outer mitochondrial membrane. Once there, Drp1 assembles into a complex around the mitochondrial circumference to drive division via a GTP-dependent ...
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Functional characterization of human DRP1

2012
Das Ziel dieser Studie war die Charakterisierung des Proteins DRP1 (dynamin related protein 1), der Hauptfaktor bei der mitochondrialen Teilung, auf biochemischer und biophysikalischer Ebene. Mitochondrien spielen unter anderem im Energiehaushalt, in der Apoptose und der Homöostase von Kalzium eine entscheidende Rolle.
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Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway

Cell Biochemistry and Biophysics
Drp1 (Dynamin-Related Protein 1) is a cytoplasmic GTPase protein encoded by the DNM1L gene that influences mitochondrial dynamics by mediating mitochondrial fission processes. Drp1 has been demonstrated to play an important role in a variety of life activities such as cell survival, proliferation, migration, and death.
Fulin, Sun, Min, Fang, Huhu, Zhang, Qinghang, Song, Shuang, Li, Ya, Li, Shuyao, Jiang, Lina, Yang   +7 more
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Regulation of Mitochondrial Division by the Drp1 Receptors

2014
Mitochondria can remodel their membranes by fusing or dividing. These processes are required for the proper development and viability of multicellular organisms. At the cellular level, fusion is important for mitochondrial Ca2+ homeostasis, mitochondrial DNA maintenance, mitochondrial membrane potential, and respiration.
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Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation

Cell Reports, 2021
Jordi Capellades, Alexandra Junza, Loïc Dayon   +2 more
exaly  

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

Cell Metabolism, 2018
Karen Schmitt, Amandine Grimm, Robert Dallmann   +2 more
exaly  

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

EMBO Journal, 2011
Jian Zhao, Tong Liu, Shaobo Jin
exaly  

Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission

Molecular Oncology, 2020
Le Shi, Yunhua Peng, Jinfang Zhang
exaly  

DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons

Cell Metabolism, 2017
Anna Santoro, Michela Campolo, Chen Liu   +2 more
exaly  

Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Circulation Research, 2015
Yoshiyuki Ikeda, Akihiro Shirakabe, Peiyong Zhai   +2 more
exaly