Results 11 to 20 of about 5,280 (85)

Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh. [PDF]

BMJ Case Rep, 2021
Drug-induced liver injury is an uncommon yet fatal cause of liver injury. Black cohosh is a herbal supplement that is derived fromActaea racemosa. It has been used for vasomotor symptoms in postmenopausal women, but it can cause liver injury. A 50-year-old Afro-American woman presented with a 2-month history of malaise, itching and severe jaundice. The
Brar HS, Marathi R.
europepmc   +4 more sources

Comparing Machine Learning Algorithms for Predicting Drug-Induced Liver Injury (DILI). [PDF]

Mol Pharm, 2020
Drug-induced liver injury (DILI) is one the most unpredictable adverse reactions to xenobiotics in humans and the leading cause of postmarketing withdrawals of approved drugs. To date, these drugs have been collated by the FDA to form the DILIRank database, which classifies DILI severity and potential.
Minerali E, Foil DH, Zorn KM, Lane TR, Ekins S.   +4 more
europepmc   +5 more sources

Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. [PDF]

Curr Drug Metab, 2018
Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases.A structured search of bibliographic databases - Web of Science Core Collection, Scopus and Medline for peer-reviewed articles on models of DILI was performed.
Kuna L, Bozic I, Kizivat T, Bojanic K, Mrso M, Kralj E, Smolic R, Wu GY, Smolic M.   +8 more
europepmc   +4 more sources

Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment. [PDF]

Ann Pharmacother, 2021
Danjuma M, Elgara M, Al-Hattab F, Abaro R, Elzouki AN.   +4 more
europepmc   +5 more sources

New classification of drug induced liver injury (DILI) in AASLD guidance: What is next? [PDF]

Hepatol Forum
Ercin CN.
europepmc   +3 more sources

Genetic variations in drug-induced liver injury (DILI): resolving the puzzle [PDF]

Frontiers in Genetics, 2012
Despite stringent requirements for drug development imposed by regulatory agencies, drug-induced liver injury (DILI) is an increasing health problem and a significant cause for failure to approve drugs, market withdrawal of commercialized medications, and adoption of regulatory measures.
Stephens, Camilla, Lucena, M Isabel, Andrade, Raúl J   +2 more
openaire   +5 more sources

Drug-induced liver injury (DILI) - mechanisms and diagnostic

Farmacja Polska, 2022
Polekowe uszkodzenia wątroby (z ang. DILI – drug-induced liver injury) są jedną z głównych przyczyn chorób wątroby w krajach rozwiniętych. Uszkodzenia te mogą być wynikiem stałej hepatotoksyczności leku lub idiosynkrazji związanej z lekiem bądź jego metabolitem. Stała hepatotoksyczność leku związana jest z mechanizmem jego działania, więc jest łatwa do
Marta Małysz, Aleksandra Więcek, Małgorzata Piechaczek, Lucyna Pomierny-Chamioło   +3 more
openaire   +2 more sources

Computational Approaches for Drug-Induced Liver Injury (DILI) Prediction: State of the Art and Challenges [PDF]

, 2021
Drug-induced liver injury (DILI) is one of the prevailing causes of fulminant hepatic failure. It is estimated that three idiosyncratic drug reactions out of four result in liver transplantation or death. Additionally, DILI is the most common reason for withdrawal of an approved drug from the market.
Béquignon, O.J.M., Pawara, G., Water, B. van de, Cronin, M.T.D., Westen, G.J.P. van   +4 more
openaire   +2 more sources

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications [PDF]

Journal of Hepatology, 2018
A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst.
William J.H. Griffiths, Jane I. Grove, Jane I. Grove, Guruprasad P. Aithal, Guruprasad P. Aithal, Adam Duckworth, Kalaiyarasi Kaliyaperumal, Robin M. Delahay, Robin M. Delahay   +8 more
openaire   +3 more sources

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET] [PDF]

Journal of Hepatology, 2021
Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a major health issue for which there is a pressing need to find novel and effective therapies.
Pierre Bagnaninchi, Alexandr Dejneka, Michel Kranendonk, Bernard Fromenty, Ozlen Konu, Oleg Lunov, Gareth J. Sullivan, Gareth J. Sullivan, Leonard J Nelson, Leonard J Nelson, Joana P. Miranda, Pau Sancho-Bru, Pau Sancho-Bru, Juan M. Falcón-Pérez, Juan M. Falcón-Pérez, M. Isabel Lucena, M. Isabel Lucena, Hui Ye, Guruprasad P. Aithal, Raúl J. Andrade, Raúl J. Andrade, Carmen García-Ruiz, Felix Royo, Francisco Javier Cubero, Francisco Javier Cubero, Alison McDonald, Alistair Elfick, José C. Fernández-Checa   +27 more
openaire   +12 more sources