Comparing Machine Learning Algorithms for Predicting Drug-Induced Liver Injury (DILI)
Molecular Pharmaceutics, 2020 Drug-induced liver injury (DILI) is one the most unpredictable adverse reactions to xenobiotics in humans and the leading cause of postmarketing withdrawals of approved drugs. To date, these drugs have been collated by the FDA to form the DILIRank database, which classifies DILI severity and potential.
Eni Minerali +4 more
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Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh
BMJ Case Reports, 2021 Drug-induced liver injury is an uncommon yet fatal cause of liver injury. Black cohosh is a herbal supplement that is derived fromActaea racemosa. It has been used for vasomotor symptoms in postmenopausal women, but it can cause liver injury. A 50-year-old Afro-American woman presented with a 2-month history of malaise, itching and severe jaundice. The
Himmat Brar, Rachana Marathi
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S2840 Drug-Induced Liver Injury (DILI) Secondary to Kratom Use
American Journal of Gastroenterology, 2021 Ali Wakil +4 more
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Autoimmune Hepatitis (AIH) Related to Drug-Induced Liver Injury (DILI) Due to Atorvastatin
CureusDrug-induced liver injury (DILI) is a rare condition characterized by hepatotoxic damage, identified through the elevation of liver function tests associated with a specific drug. Statins are among the medications linked to DILI, although this association is infrequent.
Jaime Loeza-Suárez +4 more
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Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment [PDF]
Annals of Pharmacotherapy, 2020 Mohammed Danjuma +4 more
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Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review [PDF]
Expert Opinion on Drug Metabolism & Toxicology, 2021 Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or prognosis of DILI.
Edmond Atallah +8 more
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Esbriet Pirfenidon medikamenteninduzierte Leberschdigung Drug-induced liver injury DILI [PDF]
Schweizerische Ärztezeitung, 2020 Roche Pharma Schweiz AG
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Drug-Induced Liver Injury in Tuberculosis: Mechanisms of Development and Diagnostic Methods
Juvenis Scientia, 2023 The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their ...
D. S. Sukhanov +3 more
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Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear.
Einar S. Björnsson +4 more
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Mortality associated with drug-induced liver injury (DILI) [PDF]
Translational Gastroenterology and Hepatology, 2017 Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver failure and liver injury leading to transplantation, although in most cases self-remitting when administration of the offending drug is stopped (1-3). In rare cases DILI can lead to a persistent/chronic form of injury (4).
Einar Bjornsson, Helgi Björnsson
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