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The multidrug-resistance (MDR) phenotype expressed in mammalian cell lines is complex. A cell selected with a single agent can acquire cross-resistance to a remarkably wide range of compounds which have no structural or functional similarities. The basis for cross-resistance seems to be a decreased net cellular accumulation of the drugs involved, and ...
C R, Leveille, A S, Moore
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Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid.
Xiang Meng +7 more
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Multiple Mechanisms Synergistically Induce Pseudomonas Aeruginosa Multiple Drug Resistance [PDF]
Abstract Background: This study was designed to detect the molecular epidemiological characteristics and resistant mechanism of carbapenem resistant Pseudomonas aeruginosa (CRPA) which provide reference for the prevention and treatment of hospital CRPA infection.
Lulu Yang +5 more
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Infection by Pseudomonas aeruginosa has spread worldwide, with limited options for treatment. The purpose of this study was to investigate metallo-β-lactamase-producing P.
Ana Claudia Souza Rodrigues +8 more
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Left-Sided Endocarditis Associated with Multi-Drug Resistance Acinetobacter Lwoffii [PDF]
Acinetobacter lwoffii, an important nosocomial pathogen, is a gram-negative aerobic bacillus that is a component of the normal flora on the skin, oropharynx, and perineum of about 20-25% of healthy individuals.
Hossein Ahmadi +4 more
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Troglitazone reverses the multiple drug resistance phenotype in cancer cells
Gerald F Davies1, Bernhard HJ Juurlink2, Troy AA Harkness11Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada; 2College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi ArabiaAbstract: A ...
Gerald F Davies +2 more
doaj
Objective: To assess the epidemic situation in the Russian Federation on tuberculosis with multidrug-resistant and extensively drug-resistant (MDR, XDR) of the pathogen and the effectiveness of its treatment.
A.E. ERGESHOV +5 more
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Intra-Vesical Colistin for Pseudomonas aeruginosa Urinary Tract Infections
The numbers of multiple drug-resistant Gram-negative bacterial infections are rising worldwide. The threat is increased by the lack of new antibiotics, so clinicians are turning to older drugs previously abandoned due to their recognized toxicity, such ...
Rui Encarnado Assis +6 more
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Promising Anti-Mitochondrial Agents for Overcoming Acquired Drug Resistance in Multiple Myeloma
Multiple myeloma (MM) remains an incurable tumor due to the high rate of relapse that still occurs. Acquired drug resistance represents the most challenging obstacle to the extension of survival and several studies have been conducted to understand the ...
Vanessa Innao +4 more
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Understanding and targeting resistance mechanisms in cancer
Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei +6 more
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