Results 21 to 30 of about 2,071,500 (370)

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta [PDF]

, 2017
Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to ...
Bisset, Stewart A, Choi, Young-Jun, Doyle, Stephen R, Grant, Warwick N, Hallsworth-Pepin, Kymberlie, Martin, John, Mitreva, Makedonka   +6 more
core   +3 more sources

Insights on natural products and their derivatives in tuberculosis management [PDF]

Scripta Medica
Tuberculosis (TB), a bacterial disease primarily affecting middleas well as low-income countries, poses a significant public health threat. Natural products have historically been and remain a vital source of fresh medications for treating various ...
Goyal Rajat, Susheel Kumar, Garg Kajal, Neha Rani, Chopra Hitesh, Wilson Kashish, Gupta Sumeet   +6 more
doaj   +1 more source

Plasmidic resistance to colistin mediated by mcr-1 gene in Escherichia coli clinical isolates in Argentina: A retrospective study, 2012–2018

Revista Panamericana de Salud Pública, 2020
Objective. To describe the resistance profile and the genetic characteristics of Escherichia coli isolates that harbor the mobilizable colistin resistance gene mcr-1 in Argentina. Methods. This was a retrospective study of 192 E.
Diego Faccone, Melina Rapoport, Ezequiel Albornoz, Federico Celaya, Juan De Mendieta, Denise De Belder, Celeste Lucero, Sonia Gomez, Diego Danze, Fernando Pasteran, Alejandra Corso, Mobilizable Colistin Resistance Group   +11 more
doaj   +1 more source

Draft Genome Sequences of Antibiotic-Resistant Commensal Escherichia coli [PDF]

, 2014
Antimicrobial resistance is a significant public health issue. We report here the draft genome sequences of three drug-resistant strains of commensal Escherichia coli isolated from a single healthy college student.
Garrett, Meghan, Parker, Jennifer, Stephens, Craig M.   +2 more
core   +2 more sources

Optimized Treatment Schedules for Chronic Myeloid Leukemia [PDF]

, 2016
Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients.
Dingli, David, Foo, Jasmine, He, Qie, Leder, Kevin, Zhu, Junfeng   +4 more
core   +5 more sources

Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom [PDF]

, 2001
Objectives: To identify changes since 1994 in the prevalence of resistance to anti-HIV drugs in primary HIV-1 infections in the United Kingdom. Design: Retrospective and prospective assessment of viruses obtained from people recently infected with HIV.
Baily, Guy, Cane, Patricia, Churchill, Duncan, Dean, Gill, Drake, Susan, Fisher, Martin, Pillay, Deenan, Porter, Kholoud   +7 more
core   +2 more sources

Rapid Emergence of Multidrug-Resistance among Gram Negative Isolates at a Tertiary Pediatric and Maternity Hospital in Ulaanbaatar, Mongolia

Central Asian Journal of Global Health, 2020
Introduction: Information on microbiological and susceptibility profiles of clinical isolates in Mongolia is scarce, hampering infection control and clinical care.
Susanna Felsenstein, Sarantsetseg Bira, Narangerel Altanmircheg, Enkhtur Shonkuuz, Ariuntuya Ochirpurev, David Warburton   +5 more
doaj   +1 more source

Mutational pathway determines whether drug gradients accelerate evolution of drug-resistant cells [PDF]

Phys. Rev. Lett. 109, 088101 (2012), 2012
Drug gradients are believed to play an important role in the evolution of bacteria resistant to antibiotics and tumors resistant to anti-cancer drugs. We use a statistical physics model to study the evolution of a population of malignant cells exposed to drug gradients, where drug resistance emerges via a mutational pathway involving multiple mutations.
arxiv   +1 more source

Multiscale modelling of cancer progression and treatment control : the role of intracellular heterogeneities in chemotherapy treatment [PDF]

, 2015
Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes.
Chaplain, Mark Andrew Joseph, Powathil, Gibin   +1 more
core   +1 more source

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
A Lupetti, A Viudes, C d'Enfert, CA Kumamoto, CJ Nobile, CJ Nobile, D Andes, D Shahinas, David Andes, E Mowat, EM Kojic, ET Burt, G Ramage, G Ramage, G Ramage, G Ramage, G Ramage, Gordon Ramage, J McCourtie, J Nett, J Trepel, JB Anderson, JC Young, JE Nett, Jeniel Nett, Jose L. Lopez-Ribot, JR Blankenship, JS Finkel, L Ostrosky-Zeichner, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, Leah E. Cowen, LH Pearl, LS Wilson, M Taipale, MA Pfaller, MA Pfaller, MJ Seidler, ML Richard, MM McNeil, Nicole Robbins, P Perumal, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, PK Mukherjee, Priya Uppuluri, R Pallavi, Ranjith Rajendran, Robin Charles May, RS Shapiro, RS Shapiro, S Garcia-Sanchez, S Park, S Perea, SD Singh, SJ Lin, SL LaFayette, SM Noble, SV Balashov, SZ Usmani, TE Zaoutis, Y Kaneko, YS Kim, Z Odabasi   +69 more
core   +3 more sources