Results 61 to 70 of about 1,436,718 (300)
Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study
, 2009 A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the ARV potency of therapies, but is easily affected by drug exposures,
Huang, Yangxin, Lu, Tao
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Trade-offs between drug toxicity and benefit in the multi-antibiotic resistance system underlie optimal growth of E. coli [PDF]
, 2014 Background: Efflux is a widespread mechanism of reversible drug resistance in bacteria that can be triggered by environmental stressors, including many classes of drugs.
Cluzel, Philippe, Wood, Kevin B
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Туберкулез и болезни лёгких, 2018 The article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol
N. M. Konovаlovа +3 more
doaj +1 more source
Management of multiple drug-resistant tuberculosis
Respiratory Medicine, 2003 There has been a worldwide increase in multiple drug-resistant tuberculosis (MDR-TB) which has in the past been associated with a poor prognosis. In the U.K., about half of the cases live in the London area and we have set out to obtain further information on their treatment and outcome.
Hutchison, D C S +2 more
openaire +3 more sources
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. [PDF]
, 2016 The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
Alexander, B.D. +12 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Туберкулез и болезни лёгких, 2017 In 2015 the implementation of Edicts no. 951 by the Russian Ministry of Health On Guidelines on Improvement of Respiratory Tuberculosis Treatment and Diagnostics was started.Goal of the study: to analyze the characteristics of tuberculosis patients ...
E. P. Myshkova +2 more
doaj +1 more source
Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring [PDF]
, 2018 Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a ...
Appiah, Lambert T +9 more
core +3 more sources