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Silencing of the Nicotiana benthamiana phytoendesaturase gene by root treatment of exogenous dsRNA. [PDF]
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Specific interference by ingested dsRNA
Nature, 1998A genetic interference phenomenon in the nematode Caenorhabditis elegans has been described in which expression of an individual gene can be specifically reduced by microinjecting a corresponding fragment of double-stranded (ds) RNA1. One striking feature of this process is a spreading effect: interference in a broad region of the animal is observed ...
L, Timmons, A, Fire
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Virus Research, 2004
The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes
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The dsRNA viruses represent a large, diverse group of pathogens (affecting a very wide range of host species), several of which are of medical, veterinary or agricultural importance. Many of the icosahedral dsRNA viruses show striking structural and functional similarities that reflect the similar problems that they face replicating their dsRNA genomes
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Murine immunosuppression with mycoviral dsRNA
Immunopharmacology, 1982The effect of three different size molecular weight species of mycoviral dsRNA on the immune response to sRBC was tested in C57Bl/6 mice. The various dsRNA species were extracted from electrophoresis polyacrylamide-agarose slab gels. Their molecular weights ranged from 1.0 x 10(6) daltons to 3.5 x 10(6) daltons.
C W, Hewitt, J P, Adler
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Science, 2008
Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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Toll-like receptors recognize molecules associated with pathogens and initiate inflammatory responses. For example, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), an intermediate viral replication. The TLR3 ectodomain binds as a dimer to dsRNA, but the molecular basis for signaling remains unclear.
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