Results 101 to 110 of about 5,232 (224)

Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model [PDF]

, 2015
A mouse model that recapitulates the human Ewing's sarcoma-specific chromosomal translocation was generated utilizing the Cre/loxP-mediated recombination technique.
Jay, Patrick Y, Kinoshita, Hideyuki, Kuwahara, Koichiro, Nakamura, Takuro, Nakao, Kazuwa, Noda, Tetsuo, Tanaka, Miwa, Yamaguchi, Shuichi, Yamazaki, Yukari   +8 more
core   +2 more sources

Clinical Impact of Immunoglobulin Heavy Chain Clonality in Pediatric B‐Cell Precursor Acute Lymphoblastic Leukemia

Cancer Medicine, Volume 14, Issue 21, November 2025.
IGH clonality analysis by RNA sequencing revealed distinct prognostic groups in pediatric BCP‐ALL. Our results demonstrate the value of sequencing‐based IGH profiling to enhance relapse risk assessment and guide precision monitoring strategies. ABSTRACT Introduction Recent advancements in risk stratification have greatly improved outcomes in pediatric ...
Yuta Katai, Tatsuya Kamitori, Satoshi Saida, Yoshinori Uchihara, Ryo Akazawa, Kiyotaka Isobe, Takashi Mikami, Hirohito Kubota, Itaru Kato, Katsutsugu Umeda, Hiroo Ueno, Junko Takita   +11 more
wiley   +1 more source

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia

HemaSphere, Volume 9, Issue 11, November 2025.
Abstract Advancements in the rapidity, cost efficacy, and sensitivity of next‐generation sequencing (NGS) have facilitated molecular risk stratification and precision medicine‐based treatment for pediatric leukemia. The benefit of uniform cytomolecular analyses for clinical trial risk assignment is clear.
Haley Newman, Derek Wong, Jinhua Wu, Jeffrey Schubert, Netta Golenberg, Natali Naveh, Maha Patel, Feng Xu, Sarah Charles, Jiani Chen, Elizabeth H. Denenberg, Elizabeth A. Fanning, Daniel Gallo, Tammy Luke, Morgan Thomas, Kajia Cao, Ada J. S. Chan, Munashe Holloman, Zhiqian Fan, Weixuan Fu, Stephen P. Hunger, Suzanne P. MacFarland, Kathrin M. Bernt, Lea F. Surrey, Minjie Luo, Gerald B. Wertheim, Marilyn M. Li, Sarah K. Tasian, Yiming Zhong   +28 more
wiley   +1 more source

Functional Myogenic Engraftment from Mouse iPS Cells [PDF]

, 2011
Direct reprogramming of adult fibroblasts to a pluripotent state has opened new possibilities for the generation of patient- and disease-specific stem cells.
Radbod Darabi, Weihong Pan, Darko Bosnakovski, June Baik, Michael Kyba, Rita C. R. Perlingeiro, K Takahashi, R Blelloch, M Wernig, IH Park, JA Byrne, JWM Hanna, D Xu, M Wernig, O Tsuji, Y Mizuno, MA Rudnicki, S Tajbakhsh, L Kassar-Duchossoy, F Relaix, L Bajard, M Goulding, JP Tremblay, CP Ordahl, S Tajbakhsh, IM Conboy, R Darabi, M Iacovino, K Hochedlinger, M Okabe, M Cerletti, R Couteaux, JB Harris, JB Harris, A Asakura, E Bachrach, TA Rando, A Sacco, JY Lee, M Sampaolesi, M Sampaolesi, D Montarras, BG Gálvez, J Hanna, N Maherali, J Yu, K Kaji, S Agarwal, R Maehr   +48 more
core   +1 more source

A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1‐inducible model

British Journal of Haematology, Volume 207, Issue 5, Page 1842-1854, November 2025.
An ACIN1::NUTM1‐positive ALL cell line, KOPN32, which was previously established from a relapsed infant‐ALL case, was newly identified. Comparison using 94 BCP‐ALL cell lines, an ACIN1::NUTM1‐inducible ALL model and clinical sample data revealed upregulation of HOXA9, HOXA10, SKIDA1 and BMI1, indicating direct involvement of ACIN1::NUTM1 fusion in the ...
Minori Tamai, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Atsushi Watanabe, Koshi Akahane, Kumiko Goi, Chihiro Tomoyasu, Toshihiko Imamura, Satoshi Oguri, Sumio Iwasaki, Takanori Teshima, Yasushi Yatabe, Takeshi Inukai   +13 more
wiley   +1 more source

WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma

JCI Insight, 2022
CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes.
Rovingaile Kriska M. Ponce, Nicholas J. Thomas, Nam Q. Bui, Tadashi Kondo, Ross A. Okimoto   +4 more
doaj   +1 more source

Influence of Repressive Histone and DNA Methylation upon D4Z4 Transcription in Non-Myogenic Cells. [PDF]

PLoS ONE, 2016
We looked at a disease-associated macrosatellite array D4Z4 and focused on epigenetic factors influencing its chromatin state outside of the disease-context.
Sunny Das, Brian P Chadwick
doaj   +1 more source

MyomiRs Expression in Limb Girdle Muscular Dystrophy

IUBMB Life, Volume 77, Issue 10, October 2025.
ABSTRACT This manuscript is a comprehensive review focused on the role of microRNAs (miRs)—short RNA molecules—in Limb Girdle Muscular Dystrophy (LGMD). LGMD encompasses various and heterogeneous rare genetic neuromuscular diseases, characterized by the progressive wasting and deterioration of muscle fibers, predominantly affecting the pelvic and ...
G. Breveglieri, M. T. Altieri, M. T. Rodia, R. Costa, F. Frabetti, G. Cenacchi, G. Sabbioni, M. Borgatti   +7 more
wiley   +1 more source

Cellular and animal models for facioscapulohumeral muscular dystrophy

Disease Models & Mechanisms, 2020
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common forms of muscular dystrophy and presents with weakness of the facial, scapular and humeral muscles, which frequently progresses to the lower limbs and truncal areas, causing profound
Alec M. DeSimone, Justin Cohen, Monkol Lek, Angela Lek   +3 more
doaj   +1 more source

A case report of CIC–DUX4 fusion-positive sarcoma in the pelvic cavity with targeted next-generation sequencing results [PDF]

, 2022
Qian Wu, Ying He
openalex   +1 more source