Results 121 to 130 of about 5,077 (218)

Large family cohorts of lymphoblastoid cells provide a new cellular model for investigating facioscapulohumeral muscular dystrophy [PDF]

, 2017
Facioscapulohumeral muscular dystrophy (FSHD) is associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite repeat. The resulting DNA hypomethylation and relaxation of epigenetic repression leads to increased expression of ...
Himeda, Charis L., Jones, Peter L., Jones, Takako I., Perez, Daniel P.   +3 more
core   +2 more sources

The second European interdisciplinary Ewing sarcoma research summit – A joint effort to deconstructing the multiple layers of a complex disease [PDF]

, 2016
Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second “European interdisciplinary Ewing sarcoma research summit” assembled a large group of scientific experts in the field to discuss their latest ...
Amatruda, James, Brunet, Erika, Burdach, Stefan, Cidre-Aranaz, Florencia, Kovar, Heinrich, Álava Casado, Enrique de   +5 more
core  

Loss of CIC promotes mitotic dysregulation and chromosome segregation defects [PDF]

, 2019
Background: CIC is a transcriptional repressor inactivated by loss-of-function mutations in several cancer types, including gliomas, lung cancers, and gastric adenocarcinomas.
Aparicio, Samuel A. J. R., Brothers, William, Cairncross, J. Gregory, Chan, Jennifer A., Chan, Susanna Y., Chittaranjan, Suganthi, Coope, Robin, Corbett, Richard D., Gagliardi, Alessia, Hughes, Chistopher S., Laks, Emma, LeBlanc, Veronique G., Lee, Stephen Dongsoo, Lum, Amy, Marra, Marco A., Moradian, Annie, Morin, Gregg B., Pleasance, Stephen, Song, Jungeun, Tanveer Ahmad, Shiekh, Yip, Stephen   +20 more
core   +1 more source

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design. [PDF]

, 2019
Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited ...
Baxter, Patricia, Bendak, Katerina, Berko, Esther R, Bowen, Jay, Braun, Frank K, Bryan, Anthony C, Böhm, Julia W, Cardenas, Maria F, Chen, Yidong, Coppens, Sara E, Cross, Katherine L, Diskin, Sharon J, Doddapaneni, HarshaVardhan, Du, Yunchen, Egolf, Laura E, Evans, Kathryn, Farrel, Alvin, Gaonkar, Krutika S, Gastier-Foster, Julie M, Gatto, Gregory J, Gorlick, Richard, Greene, Casey S, Haber, Michelle, Hart, Lori S, Haussler, David, Houghton, Peter J, Jayaseelan, Joy, Kalletla, Karthik, Kendsersky, Nathan M, Kolb, E Anders, Krytska, Kateryna, Kurmashev, Dias, Kurmasheva, Raushan T, Leraas, Kristen M, Li, Xiao-Nan, Lindsay, Holly B, Lock, Richard B, Lopez, Gonzalo, Maris, John M, Marshall, Glenn M, Mayoh, Chelsea, McCalmont, Hannah, McCoy, Kristyn, Modi, Apexa, Momin, Zeineen, Morton, Christopher, Mosse, Yael P, Nance, Jonas, Patel, Khushbu, Pfeil, Jacob, Qi, Lin, Raman, Pichai, Rathi, Komal S, Reynolds, C Patrick, Rokita, Jo Lynne, Sacks, Gregory I, Sanchez, Yolanda, Shu, Jack, Smith, Malcolm A, Tyrrell, Vanessa, Upton, Kristen A, Vaksman, Zalman, Vaske, Olena Morozova, Way, Gregory P, Wheeler, David A, Zhang, Huiyuan, Zhang, Wendong, Zhao, Sibo, Zheng, Siyuan   +68 more
core  

Correlation analysis of clinical parameters with epigenetic modifications in the DUX4 promoter in FSHD [PDF]

, 2012
Judit Balog, Peter Thijssen, Jessica C. de Greef, Bharati Shah, Baziel G.M. van Engelen, Kyoko Yokomori, Stephen J. Tapscott, Rabi Tawil, Silvère M. van der Maarel   +8 more
openalex   +1 more source

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells [PDF]

, 2013
Gregory J. Block, Divya Narayanan, Amanda M. Amell, Lisa M. Petek, Kathryn C. Davidson, Thomas D. Bird, Rabi Tawil, Randall T. Moon, Daniel G. Miller   +8 more
openalex   +1 more source

Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene

Cancer Communications, Volume 45, Issue 6, Page 702-708, June 2025.
Florian Henning Geyer, Alina Ritter, Seneca Kinn‐Gurzo, Tobias Faehling, Jing Li, Armin Jarosch, Carine Ngo, Endrit Vinca, Karim Aljakouch, Azhar Orynbek, Shunya Ohmura, Thomas Kirchner, Roland Imle, Laura Romero‐Pérez, Juan Díaz‐Martín, Stefanie Bertram, Enrique de Álava, Clémence Henon, Sophie Postel‐Vilnay, Ana Banito, Martin Sill, Yvonne Versleijen‐Jonkers, Benjamin Friedrich Berthold Mayer, Martin Ebinger, Monika Sparber‐Sauer, Sabine Stegmaier, Daniel Baumhoer, Wolfgang Hartmann, Jeroen Krijgsveld, David Horst, Olivier Delattre, Patrick Joseph Grohar, Thomas Georg Phillip Grünewald, Florencia Cidre‐Aranaz   +33 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

eLife
Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation that is ...
Jose Mario Bello Pineda, Robert K Bradley   +1 more
doaj   +1 more source

ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control [PDF]

, 2021
Joanna DeSalvo, Yuguang Ban, Luyuan Li, Xiaodian Sun, Zhijie Jiang, Darcy A. Kerr, Mahsa Khanlari, Maria Boulina, Mario R. Capecchi, Juha Partanen, Lin Chen, Tadashi Kondo, David M. Ornitz, Jonathan C. Trent, Josiane E. Eid   +14 more
openalex   +1 more source