Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons. [PDF]
Brain CommunAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system with complex determinants, including genetic and non-genetic factors.
Dafinca R +8 more
europepmc +3 more sources
Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons [PDF]
eLife, 2017 Mitochondrial transport in axons is critical for neural circuit health and function. While several proteins have been found that modulate bidirectional mitochondrial motility, factors that regulate unidirectional mitochondrial transport have been harder ...
Catherine M Drerup +3 more
doaj +3 more sources
Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans [PDF]
, 2015 Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the ...
Marina E. Crowder +9 more
openalex +3 more sources
Spindly is required for rapid migration of human cells [PDF]
Biology Open, 2018 Dynein is the sole processive minus-end-directed microtubule motor found in animals. It has roles in cell division, membrane trafficking, and cell migration.
Claudia Conte +3 more
doaj +5 more sources
NuMA and Ninein: Dynein Cargo-Adaptors Without a Classical Cargo [PDF]
CellsDynein is a minus-end-directed microtubule motor that transports a variety of cargoes. Cargo specificity is mediated by a class of adaptor proteins that bind to the interface between dynein and dynactin, along the length of the Arp1 filament of dynactin,
Keying Guo, Andreas Merdes
doaj +2 more sources
Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease [PDF]
Brain SciencesBackground/Objectives: Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions.
Nicholas Sanchez +5 more
doaj +2 more sources
Perry Disease: Concept of a New Disease and Clinical Diagnostic Criteria [PDF]
Journal of Movement Disorders, 2021 Perry disease is a hereditary neurodegenerative disease with autosomal dominant inheritance. It is characterized by parkinsonism, psychiatric symptoms, unexpected weight loss, central hypoventilation, and transactive-response DNA-binding protein of 43kD (
Yoshio Tsuboi +2 more
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Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. [PDF]
PLoS ONE, 2017 Dynactin is a dynein-regulating protein that increases the processivity of dynein movement on microtubules. Recent studies have shown that a tripartite complex of dynein-dynactin-Bicaudal D2 is essential for highly processive movement.
Takuya Kobayashi +3 more
doaj +1 more source
Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein
Nature Communications, 2023 Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the ...
Kyoko Okada +6 more
doaj +1 more source
Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid. [PDF]
PLoS ONE, 2011 The mitotic checkpoint functions to ensure accurate chromosome segregation by regulating the progression from metaphase to anaphase. Once the checkpoint has been satisfied, it is inactivated in order to allow the cell to proceed into anaphase and ...
Jakub K Famulski +3 more
doaj +1 more source