VezA/vezatin facilitates proper assembly of the dynactin complex in vivo. [PDF]
Cell RepCytoplasmic dynein-mediated intracellular transport needs the multi-component dynactin complex for cargo binding and motor activation. However, cellular factors involved in dynactin assembly remain unexplored.
Zhang J +4 more
europepmc +2 more sources
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
Nature Communications, 2022 Organellar transport is carefully regulated, and endolysosome localized ARL8 is important for kinesin recruitment and anterograde movement. Here, the authors show that RUFY3 and RUFY4 promote retrograde transport of endolysosomes by mediating interaction
Tal Keren-Kaplan +6 more
doaj +2 more sources
Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes
eLife, 2023 Kazrin is a protein widely expressed in vertebrates whose depletion causes a myriad of developmental defects, in part derived from altered cell adhesion and migration, as well as failure to undergo epidermal to mesenchymal transition.
Ines Hernandez-Perez +7 more
doaj +2 more sources
Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein [PDF]
BMC Evolutionary Biology, 2012 Background Dynactin is a large multisubunit protein complex that enhances the processivity of cytoplasmic dynein and acts as an adapter between dynein and the cargo.
Hammesfahr Björn, Kollmar Martin
doaj +4 more sources
Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons. [PDF]
Brain CommunAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system with complex determinants, including genetic and non-genetic factors.
Dafinca R +8 more
europepmc +2 more sources
Molecular mechanism of dynein-dynactin complex assembly by LIS1. [PDF]
ScienceCytoplasmic dynein is a microtubule motor vital for cellular organization and division. It functions as a ~4-megadalton complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor.
Singh K +5 more
europepmc +2 more sources
Nature Communications, 2018 A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes.
In-Gyun Lee +5 more
doaj +2 more sources
Brazilian Journal of Medical and Biological ResearchAxons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell bodies.
Yongmei Wu +14 more
doaj +2 more sources
The Dynactin Complex Enhances the Speed of Microtubule-Dependent Motions of Adenovirus Both Towards and Away from the Nucleus [PDF]
Viruses, 2011 Unlike transport vesicles or organelles, human adenovirus (HAdV) directly binds to the microtubule minus end-directed motor dynein for transport to the nucleus. The dynein cofactor dynactin enhances nuclear transport of HAdV and boosts infection.
Martin F. Engelke +3 more
doaj +2 more sources
Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease [PDF]
Brain SciencesBackground/Objectives: Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions.
Nicholas Sanchez +5 more
doaj +2 more sources