Results 91 to 100 of about 17,522 (280)

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport

Nature Communications, 2023
The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to ...
John T. Canty, Andrew Hensley, Merve Aslan, Amanda Jack, Ahmet Yildiz   +4 more
doaj   +1 more source

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein [PDF]

, 2012
Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed.
A. Friedman, A. G. Hendricks, A. G. Hendricks, A. J. Roberts, A. Kunwar, A. P. Carter, A. V. Kuznetsov, A. V. Kuznetsov, Anotida Madzvamuse, C. Korn, C. L. Brown, Caroline A. Garrett, D. A. Smith, D. Tsygankov, E. Bananis, J. L. Ross, J. Munárriz, J. W. Driver, J. W. Murray, J. W. Wojcieszyn, K. Imamula, K. M. Ori-McKenney, K. S. Zadeh, L. W. Duchen, Laurie Crossley, M. A. Gee, M. B. Harms, M. Bier, M. H. Willemsen, M. Hafezparast, M. N. Weedon, M. Schliwa, M. Schuster, M. Schuster, Majid Hafezparast, O. J. Driskell, P. Ashwin, R. D. Vale, S. A. Burgess, S. Ally, S. C. Schaffner, S. Hoepfner, S. Lubery, S. Mitragotri, S. Mukherji, T. D. Pollard, T. Kon, V. Soppina, W. Deng, X. J. Chen, Y. Gao, Y. Imafuku, Y. Zhang, Y. Zhang   +53 more
core   +1 more source

Dynactin Is Required for Microtubule Anchoring at Centrosomes [PDF]

The Journal of Cell Biology, 1999
The multiprotein complex, dynactin, is an integral part of the cytoplasmic dynein motor and is required for dynein-based motility in vitro and in vivo. In living cells, perturbation of the dynein–dynactin interaction profoundly blocks mitotic spindle assembly, and inhibition or depletion of dynein or dynactin from meiotic or mitotic cell extracts ...
N J, Quintyne, S R, Gill, D M, Eckley, C L, Crego, D A, Compton, T A, Schroer   +5 more
openaire   +2 more sources

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

eLife, 2018
We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein ...
Thomas E Sladewski, Neil Billington, M Yusuf Ali, Carol S Bookwalter, Hailong Lu, Elena B Krementsova, Trina A Schroer, Kathleen M Trybus   +7 more
doaj   +1 more source

Homolog pairing during meiosis : dyneins on the move [PDF]

, 2010
Meiosis is a specialized form of cell division that generates haploid gametes from diploid cells. This is achieved by having 1 round of DNA replication followed by 2 rounds of nuclear division.
Arumugam, Prakash
core   +1 more source

Tissue Proteomics of Feline Mammary Carcinoma: Differences in Protein Profiles Among Histological Grades Using Liquid Chromatography–Tandem Mass Spectrometry

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and therapy selection.
Pruettha Arunvornlop, Sekkarin Ploypetch, Walasinee Sakcamduang, Sirintra Sirivisoot, Tanit Kasantikul, Sittiruk Roytrakul, Narumon Phaonakrop, Nlin Arya   +7 more
wiley   +1 more source

The Dynactin Complex Enhances the Speed of Microtubule-Dependent Motions of Adenovirus Both Towards and Away from the Nucleus

Viruses, 2011
Unlike transport vesicles or organelles, human adenovirus (HAdV) directly binds to the microtubule minus end-directed motor dynein for transport to the nucleus. The dynein cofactor dynactin enhances nuclear transport of HAdV and boosts infection.
Martin F. Engelke, Christoph J. Burckhardt, Urs F. Greber, Matthias K. Morf   +3 more
doaj   +1 more source

Mechanisms of spindle positioning. [PDF]

, 2013
Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions that are crucial for animal development and oocyte maturation, respectively.
McNally, Francis J
core   +1 more source

Regulation of dynein‐dynactin‐driven vesicular transport [PDF]

Traffic, 2017
Most of the long‐range intracellular movements of vesicles, organelles and other cargoes are driven by microtubule (MT)‐based molecular motors. Cytoplasmic dynein, a multisubunit protein complex, with the aid of dynactin, drives transport of a wide variety of cargoes towards the minus end of MTs.
openaire   +2 more sources