Results 91 to 100 of about 9,677 (245)

Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

eLife, 2017
The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg, Dmitry Nashchekin, Maximilian Jakobs, Andrew P Carter, Philipp Khuc Trong, Raymond E Goldstein, Daniel St Johnston   +6 more
doaj   +1 more source

Diet and cell size both affect queen-worker differentiation through DNA methylation in honey bees (Apis mellifera, Apidae). [PDF]

PLoS ONE, 2011
Young larvae of the honey bee (Apis mellifera) are totipotent; they can become either queens (reproductives) or workers (largely sterile helpers). DNA methylation has been shown to play an important role in this differentiation. In this study, we examine
Yuan Yuan Shi, Zachary Y Huang, Zhi Jiang Zeng, Zi Long Wang, Xiao Bo Wu, Wei Yu Yan   +5 more
doaj   +1 more source

The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex

Science Advances, 2020
Dendritic actin networks grow in an autocatalytic manner starting from the uncapped minifilament of dynactin. Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex.
A. Fokin, V. David, Ksenia Oguievetskaia, E. Derivery, Caroline E. Stone, Luyan Cao, N. Rocques, Nicolas Molinie, V. Henriot, M. Aumont-Nicaise, M. Hinckelmann, F. Saudou, Christophe Le Clainche, A. Carter, G. Romet-Lemonne, A. Gautreau   +15 more
semanticscholar   +1 more source

Whole‐Genome Resequencing Provides Novel Insights Into the Genetic Diversity, Population Structure, and Patterns of Runs of Homozygosity in Mud Crab (Scylla paramamosain)

Evolutionary Applications, Volume 18, Issue 9, September 2025.
ABSTRACT Mud crab (Scylla paramamosain) is an economically important aquaculture crustacean species in China and Southeast Asia countries. However, the catches of wild mud crabs declined sharply due to overfishing and environmental pollution. Therefore, it is necessary to understand the current genetic resources and population history of mud crab (S ...
Xiyi Zhou, Min Ouyang, Yin Zhang, Mhd Ikhwanuddin, Hongyu Ma, Shaopan Ye   +5 more
wiley   +1 more source

BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M

Nature Communications, 2023
The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos.
Núria Gallisà-Suñé, Paula Sànchez-Fernàndez-de-Landa, Fabian Zimmermann, Marina Serna, Laura Regué, Joel Paz, Oscar Llorca, Jens Lüders, Joan Roig   +8 more
doaj   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, Volume 292, Issue 18, Page 4870-4897, September 2025.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Identification of Rab41/6d effectors provides an explanation for the differential effects of Rab41/6d and Rab6a/a' on Golgi organization

Frontiers in Cell and Developmental Biology, 2016
Unexpectedly, members of the Rab VI subfamily exhibit considerable variation in their effects on Golgi organization and trafficking. By fluorescence microscopy, neither depletion nor overexpression of the GDP-locked form of Rab6a/a’, the first trans ...
Shijie eLiu, Waqar eMajeed, Tetyana eKudlyk, Vladimir eLupashin, Brian eStorrie   +4 more
doaj   +1 more source

Ropinirole Functions Through a Dopamine Receptor D2‐Independent Mechanism to Ameliorate Amyotrophic Lateral Sclerosis Phenotypes in TARDBP‐Mutant iPSC‐Derived Motor Neurons

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Ropinirole, a dopamine D2 receptor (DRD2) agonist, protects motor neurons harboring ALS‐linked TARDBP mutations via both DRD2‐dependent and DRD2‐independent mechanisms. Notably, the DRD2‐independent pathway inhibits elevated reactive oxygen species (ROS), abnormal gene expression, aberrant RNA splicing, and neuronal hyperexcitation—key pathogenic ...
Hirotsugu Asano, Tetsuya Kawaguchi, Chris Kato, Satoru Morimoto, Masato Yano, Maki Minaguchi, Daisuke Yasuda, Komei Fukushima, Hideyuki Okano   +8 more
wiley   +1 more source

Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin

Nature Chemical Biology, 2019
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor.
M. M. ElShenawy, J. Canty, Liya F. Oster, Luke S. Ferro, Zhou Zhou, S. Blanchard, A. Yildiz   +6 more
semanticscholar   +1 more source

Role of dynein–dynactin complex, kinesins, motor adaptors, and their phosphorylation in dendritogenesis

Journal of Neurochemistry, 2020
One of the characteristic features of different classes of neurons that is vital for their proper functioning within neuronal networks is the shape of their dendritic arbors.
A. Tempes, J. Węsławski, A. Brzozowska, J. Jaworski   +3 more
semanticscholar   +1 more source