Results 101 to 110 of about 17,522 (280)
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2015 Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues
Orwa eAboud +5 more
doaj +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Transport of fungal RAB11 secretory vesicles involves myosin-5, dynein/dynactin/p25, and kinesin-1 and is independent of kinesin-3 [PDF]
, 2017 15 p.-8 fig.Hyphal tip cells of the fungus Aspergillus nidulans are useful for studying long-range intracellular traffic. Post-Golgi secretory vesicles (SVs) containing the RAB11 orthologue RabE engage myosin-5 as well as plus end– and minus end–directed
Pantazopoulou, Areti +3 more
core +1 more source
The human cytoplasmic dynein interactome reveals novel activators of motility
eLife, 2017 In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine +8 more
doaj +1 more source
Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. [PDF]
PLoS Biology, 2013 Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease.
Jacob E Lazarus +3 more
doaj +1 more source
PAR-dependent and geometry-dependent mechanisms of spindle positioning. [PDF]
, 2003 During intrinsically asymmetric division, the spindle is oriented onto a polarized axis specified by a group of conserved PAR proteins. Extrinsic geometric asymmetry generated by cell shape also affects spindle orientation in some systems, but how ...
Hayashi, Adam +3 more
core
eLife, 2017 The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised microtubule cytoskeleton that grows from non ...
Ross Nieuwburg +6 more
doaj +1 more source
A mathematical understanding of how cytoplasmic dynein walks on microtubules [PDF]
, 2018 Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles, a mechanical model
Hafezparast, M, Madzvamuse, A, Trott, L
core +2 more sources
Trina Schroer: What’s cooking on dynactin [PDF]
Journal of Cell Biology, 2013 Schroer studies the composition and activity of dynactin.
openaire +1 more source