Results 11 to 20 of about 9,677 (245)
Cryo-EM shows how dynactin recruits two dyneins for faster movement [PDF]
Nature, 2018 Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes.
L. Urnavicius +6 more
openalex +2 more sources
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
eLife, 2018 To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery.
Masako Okumura +3 more
doaj +2 more sources
Journal of Diabetes Investigation, 2021 Aims/Introduction It was reported previously that N4bp2l1 expression increases in 3T3‐L1 cells in a differentiation‐dependent manner and N4bp2l1 knockdown suppresses adipocyte differentiation.
Kazuhisa Watanabe +3 more
doaj +2 more sources
Dynactin Function in Mitotic Spindle Positioning [PDF]
Traffic, 2008 Dynactin is a multisubunit protein complex necessary for dynein function. Here, we investigated the function of dynactin in budding yeast. Loss of dynactin impaired movement and positioning of the mitotic spindle, similar to loss of dynein. Dynactin subunits required for function included p150Glued, dynamitin, actin‐related protein (Arp) 1 and p24 ...
Jeffrey K. Moore, Jun Li, John A. Cooper
openalex +4 more sources
Perry Disease: Concept of a New Disease and Clinical Diagnostic Criteria [PDF]
Journal of Movement Disorders, 2021 Perry disease is a hereditary neurodegenerative disease with autosomal dominant inheritance. It is characterized by parkinsonism, psychiatric symptoms, unexpected weight loss, central hypoventilation, and transactive-response DNA-binding protein of 43kD (
Yoshio Tsuboi +2 more
doaj +1 more source
BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin-1 by Complementary Mechanisms. [PDF]
TrafficKinesin‐1 is auto‐inhibited and binds microtubules weakly. Binding of kinesin‐1 to the adaptor protein BicD enhances processive motion, while the microtubule‐associated protein MAP7 recruits more kinesin to the microtubule and enhances run length.
Ali MY +4 more
europepmc +2 more sources
Dynein and dynactin move long-range but are delivered separately to the axon tip
bioRxiv, 2023 Axonal transport is essential for neuronal survival. This is driven by microtubule motors including dynein, which transports cargo from the axon tip back to the cell body. This function requires its cofactor dynactin and regulators LIS1 and NDEL1. Due to
Alexander D Fellows +4 more
semanticscholar +1 more source
Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. [PDF]
PLoS ONE, 2017 Dynactin is a dynein-regulating protein that increases the processivity of dynein movement on microtubules. Recent studies have shown that a tripartite complex of dynein-dynactin-Bicaudal D2 is essential for highly processive movement.
Takuya Kobayashi +3 more
doaj +1 more source
Molecular mechanism of dynein-dynactin activation by JIP3 and LIS1
bioRxiv, 2023 Microtubule motors, like cytoplasmic dynein-1, are tightly regulated to prevent inappropriate activity in cells. Dynein functions as a ∼4 MDa complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor.
Kashish Singh +5 more
semanticscholar +1 more source