Results 21 to 30 of about 9,677 (245)

Dynactin Is Necessary for Synapse Stabilization [PDF]

Neuron, 2002
We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex.
Richard D. Fetter, Graeme W. Davis, Benjamin A. Eaton   +2 more
openaire   +3 more sources

HEATR5B associates with dynein‐dynactin and promotes motility of AP1‐bound endosomal membranes

EMBO Journal, 2023
The microtubule motor dynein mediates polarised trafficking of a wide variety of organelles, vesicles and macromolecules. These functions are dependent on the dynactin complex, which helps recruit cargoes to dynein's tail and activates motor movement ...
Vanesa Madan, Lucas Albacete-Albacete, Li Jin, Pietro Scaturro, Joseph L Watson, Nadine Muschalik, Farida Begum, Jérôme Boulanger, Karl Bauer, M. Kiebler, Emmanuel Derivery, S. Bullock   +11 more
semanticscholar   +1 more source

Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein

Nature Communications, 2023
Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the ...
Kyoko Okada, Bharat R. Iyer, Lindsay G. Lammers, Pedro A. Gutierrez, Wenzhe Li, Steven M. Markus, Richard J. McKenney   +6 more
doaj   +1 more source

HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranes

bioRxiv, 2023
The dynein motor complex mediates polarised trafficking of a wide variety of organelles, intracellular vesicles and macromolecules. These functions are dependent on the dynactin complex, which helps recruit cargoes to dynein’s tail region and activates ...
Vanesa Madan, Lucas Albacete Albacete, Li Jin, Pietro Scaturro, Joseph L. Watson, Nadine Muschalik, Farida Begum, J. Boulanger, K. Bauer, M. Kiebler, E. Derivery, S. Bullock   +11 more
semanticscholar   +1 more source

p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation [PDF]

Journal of Biological Chemistry, 2018
Cytoplasmic dynein binds its cargoes via the dynactin complex and cargo adapters, and the dynactin pointed-end protein p25 is required for dynein-dynactin binding to the early endosomal dynein adapter HookA (Hook in the fungus Aspergillus nidulans). However, it is unclear whether the HookA-dynein-dynactin interaction requires p27, another pointed-end ...
Jun Zhang, Xin Xiang, Rongde Qiu
openaire   +3 more sources

dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. [PDF]

PLoS ONE, 2013
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly ...
Kensuke Ikenaka, Kaori Kawai, Masahisa Katsuno, Zhe Huang, Yue-Mei Jiang, Yohei Iguchi, Kyogo Kobayashi, Tsubasa Kimata, Masahiro Waza, Fumiaki Tanaka, Ikue Mori, Gen Sobue   +11 more
doaj   +1 more source

TDP-43 Cryptic RNAs in Perry Syndrome: Differences across Brain Regions and TDP-43 Proteinopathies. [PDF]

Mov Disord
In Perry syndrome caudate nucleus, TDP‐43 pathology and dysfunction lead to the cryptic splicing of eight RNA targets as well as HDGFL2 cryptic protein. In the substantia nigra, only one cryptic target was significantly elevated, and no cryptic protein was detected. Taken together, this suggests regional specificity of cryptic splicing.
Pickles SR, Gonzalez Bejarano J, Narayan A, Daughrity L, Maroto Cidfuentes C, Reeves MM, Yue M, Castellanos Otero P, Estades Ayuso V, Dunmore J, Song Y, Tong J, DeTure M, Rawlinson B, Castanedes-Casey M, Dulski J, Cerquera-Cleves C, Zhang Y, Josephs KA, Dickson DW, Petrucelli L, Wszolek ZK, Prudencio M.   +22 more
europepmc   +2 more sources

Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking [PDF]

Scientific Reports, 2017
AbstractThe transmembrane prostate androgen-induced protein (TMEPAI) has been reported to be elevated in various tumor cells, is localized to the lysosome and promotes lysosome stability. The molecular mechanism of TMEPAI trafficking however to the lysosome is unknown.
Shenheng Luo, Lei Jing, Tian Zhao, Yuyin Li, Zhenxing Liu, Aipo Diao   +5 more
openalex   +4 more sources

Microtubule Motors: Doin’ It without Dynactin [PDF]

Current Biology, 2013
The minus-end directed microtubule motor protein cytoplasmic dynein contributes to many aspects of cell division and it is generally believed that these mitotic functions require the dynein activator and processivity factor, dynactin. New research now shows that dynein accomplishes many of its mitotic functions without dynactin.
Patricia Wadsworth, Wei-Lih Lee
openaire   +2 more sources

Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid. [PDF]

PLoS ONE, 2011
The mitotic checkpoint functions to ensure accurate chromosome segregation by regulating the progression from metaphase to anaphase. Once the checkpoint has been satisfied, it is inactivated in order to allow the cell to proceed into anaphase and ...
Jakub K Famulski, Larissa J Vos, Jerome B Rattner, Gordon K Chan   +3 more
doaj   +1 more source