Results 21 to 30 of about 17,522 (280)
Conformational diversity of dynactin sidearm and domain organization of its subunit p150 [PDF]
Molecular Biology of the Cell, 2020 Dynactin is a principal regulator of the minus-end directed microtubule motor dynein. The sidearm of dynactin is essential for binding to microtubules and regulation of dynein activity. Although our understanding of the structure of the dynactin backbone
Kei Saito +8 more
openalex +2 more sources
Interaction of tau protein with the dynactin complex [PDF]
The EMBO Journal, 2007 Tau is an axonal microtubule-associated protein involved in microtubule assembly and stabilization. Mutations in Tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and tau aggregates are present in Alzheimer's disease and other tauopathies.
Enrico Magnani +8 more
openalex +4 more sources
VezA/vezatin facilitates proper assembly of the dynactin complex in vivo. [PDF]
Cell RepCytoplasmic dynein-mediated intracellular transport needs the multi-component dynactin complex for cargo binding and motor activation. However, cellular factors involved in dynactin assembly remain unexplored.
Zhang J +4 more
europepmc +2 more sources
Molecular mechanism of dynein-dynactin activation by JIP3 and LIS1
bioRxiv, 2023 Microtubule motors, like cytoplasmic dynein-1, are tightly regulated to prevent inappropriate activity in cells. Dynein functions as a ∼4 MDa complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor.
Kashish Singh +5 more
semanticscholar +1 more source
HEATR5B associates with dynein‐dynactin and promotes motility of AP1‐bound endosomal membranes
EMBO Journal, 2023 The microtubule motor dynein mediates polarised trafficking of a wide variety of organelles, vesicles and macromolecules. These functions are dependent on the dynactin complex, which helps recruit cargoes to dynein's tail and activates motor movement ...
Vanesa Madan +11 more
semanticscholar +1 more source
bioRxiv, 2023 The dynein motor complex mediates polarised trafficking of a wide variety of organelles, intracellular vesicles and macromolecules. These functions are dependent on the dynactin complex, which helps recruit cargoes to dynein’s tail region and activates ...
Vanesa Madan +11 more
semanticscholar +1 more source
dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration. [PDF]
PLoS ONE, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly ...
Kensuke Ikenaka +11 more
doaj +1 more source
Dynactin Is Necessary for Synapse Stabilization [PDF]
Neuron, 2002 We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex.
Eaton, Benjamin A +2 more
openaire +2 more sources
Microtubule Motors: Doin’ It without Dynactin [PDF]
Current Biology, 2013 The minus-end directed microtubule motor protein cytoplasmic dynein contributes to many aspects of cell division and it is generally believed that these mitotic functions require the dynein activator and processivity factor, dynactin. New research now shows that dynein accomplishes many of its mitotic functions without dynactin.
Wadsworth, Patricia, Lee, Wei-Lih
openaire +2 more sources
The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex [PDF]
Science Advances, 2020 Dendritic actin networks grow in an autocatalytic manner starting from the uncapped minifilament of dynactin. Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex.
Artem I. Fokin +15 more
openalex +2 more sources