Results 51 to 60 of about 9,677 (245)
Scientific Reports, 2018 The minus-end-directed microtubule motor cytoplasmic dynein requires the dynactin complex for in vivo functions. The backbone of the vertebrate dynactin complex is the Arp1 (actin-related protein 1) mini-filament whose barbed end binds to the ...
Jun Zhang, Rongde Qiu, Xin Xiang
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Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end
EMBO Journal, 2021 Dynactin is a 1.1 MDa complex that activates the molecular motor dynein for ultra‐processive transport along microtubules. In order to do this, it forms a tripartite complex with dynein and a coiled‐coil adaptor.
C. K. Lau +5 more
semanticscholar +1 more source
Spindly is required for rapid migration of human cells
Biology Open, 2018 Dynein is the sole processive minus-end-directed microtubule motor found in animals. It has roles in cell division, membrane trafficking, and cell migration.
Claudia Conte +3 more
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Regulation of dynein‐dynactin‐driven vesicular transport [PDF]
Traffic, 2017 Most of the long‐range intracellular movements of vesicles, organelles and other cargoes are driven by microtubule (MT)‐based molecular motors. Cytoplasmic dynein, a multisubunit protein complex, with the aid of dynactin, drives transport of a wide variety of cargoes towards the minus end of MTs.
Jia‐Jia Liu
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Lis1 activates dynein motility by modulating its pairing with dynactin
Nature Cell Biology, 2020 Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an inhibitor or an activator of mammalian dynein motility.
M. M. ElShenawy +5 more
semanticscholar +1 more source
Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons
eLife, 2017 Mitochondrial transport in axons is critical for neural circuit health and function. While several proteins have been found that modulate bidirectional mitochondrial motility, factors that regulate unidirectional mitochondrial transport have been harder ...
Catherine M Drerup +3 more
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On and off controls within dynein–dynactin on native cargoes
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The dynein–dynactin nanomotor is required for vastly diverse cellular functions, including cell division and cargo transport. Why dynactin interacts separately with the dynein motor and with microtubules is poorly understood and ...
Paulomi Sanghavi +4 more
semanticscholar +1 more source
New insights into the mechanism of dynein motor regulation by lissencephaly-1
eLife, 2020 Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M Markus +2 more
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Dynactin: Coordinating Motors with Opposite Inclinations [PDF]
Current Biology, 2003 In eukaryotic cells, many organelles are transported bidirectionally along microtubules by kinesin and dynein. These opposite-polarity motors appear to be coordinated to avoid interfering with each other's function. New work has provided the first molecular insight into how such coordination might occur.
openaire +3 more sources
Lissencephaly-1 is a context-dependent regulator of the human dynein complex
eLife, 2017 The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach +6 more
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