Results 61 to 70 of about 9,677 (245)
Cargo-Mediated Activation of Cytoplasmic Dynein in vivo
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 is a minus-end-directed microtubule motor that transports a variety of cargoes including early endosomes, late endosomes and other organelles.
Xin Xiang, Rongde Qiu
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Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. [PDF]
PLoS ONE, 2013 Cytoplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling and cell division. The principal subunits that mediate this interaction are the dynein intermediate chain (IC) and the dynactin p150(Glued); however ...
Amanda E Siglin +8 more
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ZW10 Helps Recruit Dynactin and Dynein to the Kinetochore [PDF]
The Journal of Cell Biology, 1998 Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores. Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar ...
Starr, Daniel A +3 more
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Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma
Technology in Cancer Research and Treatment, 2021 Objective: This present study aims to investigate the potential prognostic values of dynactin genes (DCTN) for predicting the overall survival (OS) in low-grade glioma (LGG) patients. Methods: The DCTN mRNA expression data were downloaded from The Cancer
Xiaotao Su +3 more
semanticscholar +1 more source
Nde1 promotes Lis1-mediated activation of dynein
Nature Communications, 2023 Cytoplasmic dynein drives the motility and force generation functions towards the microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an active transport complex is facilitated by Lis1 and Nde1/Ndel1.
Yuanchang Zhao, Sena Oten, Ahmet Yildiz
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The Role of the Dynactin Complex in Intracellular Motility
, 1998 Dynactin is a multisubunit complex that binds to the minus-end-directed microtubule motor cytoplasmic dynein and may provide a link between the motor and its cargo. Results from genetic studies in Saccharomyces cerevisiae, Neurospora crassa, Aspergillus nidulans, and Drosophila have suggested that cytoplasmic dynein and dynactin function in the same ...
Erika L.F. Holzbaur +2 more
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Analysis of the Dynein-Dynactin Interaction In Vitro and In Vivo [PDF]
Molecular Biology of the Cell, 2003 Cytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context.
Christa L. Brown +4 more
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NuMA recruits dynein activity to microtubule minus-ends at mitosis
eLife, 2017 To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into
Christina L Hueschen +3 more
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RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
Nature Communications, 2022 Lysosomes move along microtubule tracks, and Arl8b is known to stimulate their anterograde transport. Here, the authors identified RUFY3 as an Arl8b effector that interacts with dynein-dynactin to drive retrograde transport and perinuclear lysosome ...
Gaurav Kumar +7 more
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Structure and function of dynactin
Seminars in Cell & Developmental Biology, 1996 Abstract Dynactin is a 1·2 mDa protein complex initially isolated as an activator of cytoplasmic dynein-driven vesicle movementin vitro. Genetic studies have verified that dynactin participates in dynein-based transport events as varied as nuclear localization and axonal transport.
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