Results 71 to 80 of about 9,677 (245)
Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors
Frontiers in Immunology, 2018 The different cytoskeleton systems and their connecting molecular motors move vesicles and intracellular organelles to shape cells. Polarized cells with specialized functions display an exquisite spatio-temporal regulation of both cytoskeletal and ...
Noa Beatriz Martín-Cófreces +3 more
doaj +1 more source
Nature Communications, 2023 The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to ...
John T. Canty +4 more
doaj +1 more source
m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An +7 more
wiley +1 more source
Trina Schroer: What’s cooking on dynactin [PDF]
Journal of Cell Biology, 2013 Schroer studies the composition and activity of dynactin.
openaire +2 more sources
A septin GTPase scaffold of dynein–dynactin motors triggers retrograde lysosome transport
bioRxiv, 2020 The metabolic and signaling functions of lysosomes depend on their intracellular positioning and trafficking, but the underlying mechanisms are little understood.
Ilona A. Kesisova +2 more
semanticscholar +1 more source
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, EarlyView.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Ultrastructure of Dynactin Complex: A Mediator of Cytoplasmic Dynein [PDF]
Biophysical Journal, 2015 The ∼1.0 megadalton dynactin complex interacts with cytoplasmic dynein to increase its processivity during minus-end-directed transport of cargo along microtubules (MT). The detailed molecular understanding of how dynactin regulates dynein motility is still elusive due to lack of structural information of the complex.
Stephanie A. Ketcham +3 more
openaire +2 more sources
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, EarlyView.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex
eLife, 2018 We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein ...
Thomas E Sladewski +7 more
doaj +1 more source
RUFY3 and RUFY4 are ARL8 effectors that couple lysosomes to dynein-dynactin
, 2021 The small GTPase ARL8 associates with lysosomes and recruits several effectors that mediate coupling to kinesins for anterograde transport, as well as tethering for eventual fusion with other organelles. Herein we report the identification of the “RUN-
Tal Keren-Kaplan +6 more
semanticscholar +1 more source