Results 81 to 90 of about 9,677 (245)
The FEBS Journal, EarlyView.Activation of CLIP170 by CDKL5 in wild‐type (WT) cells promotes its open conformation and association with tyrosinated microtubule (MT) plus‐ends (+), where it works as a docking site to recruit the dynactin–dynein–cargo complex, promoting the initiation of retrograde transport. In knock‐out (KO) neurons, CLIP170 is mainly present in a closed (inactive)
Serena Baldin +4 more
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Protein Disorder in Dynein Regulation by Dynactin and NudE [PDF]
Biophysical Journal, 2015 Cytoplasmic dynein is a multi-subunit protein complex responsible for retrograde transport of diverse cellular cargoes along microtubules. Dynein is comprised of heavy chains responsible for motor activity, and intermediate chain (IC) and light chains for cargo attachment and regulation.
Jing Jie, Elisar Barbar
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Frontiers in Cellular Neuroscience, 2015 Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues
Orwa eAboud +5 more
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Atypical Frontotemporal Dementia Associated With SQSTM1 Gene Mutation: A Clinicopathological Case
Neuropathology, Volume 45, Issue 6, December 2025.ABSTRACT A 78‐year‐old man presented with a six‐year history of progressive memory decline, initially manifesting as recent memory impairment and mild anomia, which gradually evolved into motor clumsiness, gait disturbances, language difficulties, behavioral changes, and late‐onset parkinsonism. He had been diagnosed with Paget disease of bone (PDB) at
Christian Espinoza‐Vinces +8 more
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Dynactin polices two-way organelle traffic [PDF]
The Journal of Cell Biology, 2003 How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes.
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The human cytoplasmic dynein interactome reveals novel activators of motility
eLife, 2017 In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtubule minus ends.
William B Redwine +8 more
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Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, Volume 12, Issue 37, October 6, 2025.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
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Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. [PDF]
PLoS Biology, 2013 Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease.
Jacob E Lazarus +3 more
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Frontiers in Cell and Developmental Biology, 2021 The Arp2/3 complex generates branched actin networks at different locations of the cell. The WASH and WAVE Nucleation Promoting Factors (NPFs) activate the Arp2/3 complex at the surface of endosomes or at the cell cortex, respectively. In this review, we
Artem I. Fokin +2 more
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Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.The interaction between inflammasomes and autophagy is crucial for maintaining the balance between necessary immune responses and the avoidance of excessive inflammation. Autophagy can inhibit the activation of the NLRP3 inflammasome by degrading endogenous activators, such as damaged mitochondria that produce reactive oxygen species (ROS), as well as ...
Sai Liu, Jingzhou Zhang
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