Results 61 to 70 of about 13,638,973 (240)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

HybridDWAVO: Finite-horizon velocity-obstacle filtering within the dynamic window approach for dynamic obstacle avoidance

This article proposes HybridDWAVO, a deterministic local-planning framework that combines the dynamics-aware trajectory generation of the dynamic window approach with the predictive collision-avoidance capability of the velocity obstacle method.
Bongsu Hahn
core   +1 more source

A Safe Maritime Path Planning Fusion Algorithm for USVs Based on Reinforcement Learning A* and LSTM-Enhanced DWA

Sensors
In complex maritime environments, the safety of path planning for Unmanned Surface Vehicles (USVs) remains a significant challenge. Existing methods for handling dynamic obstacles often suffer from inadequate predictability and generate non-smooth ...
Zhenxing Zhang, Qiujie Wang, Xiaohui Wang, Mingkun Feng   +3 more
doaj   +1 more source

An Improved SOM-Based Method for Multi-Robot Task Assignment and Cooperative Search in Unknown Dynamic Environments

Energies, 2020
The methods of task assignment and path planning have been reported by many researchers, but they are mainly focused on environments with prior information.
Hongwei Tang, Anping Lin, Wei Sun, Shuqi Shi   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A dynamic lot-sizing model with demand time windows [PDF]

One of the basic assumptions of the classical dynamic lot-sizing model is that the aggregate demand of a given period must be satisfied in that period.
Lee, C.Y., Wagelmans, A.P.M., Cetinkaya, S.   +2 more
core  

Remote Shared Control With Dynamic Window Approach in Unknown Narrow Environment

IEEE Access
For telepresence mobile robots, avoiding collisions in unknown narrow environments has been a significant challenge. This paper defines an unknown environment as having no prior map and a narrow environment as having obstacles close to the robot’s
Xiaoge Feng, Naoki Motoi
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source