Results 71 to 80 of about 1,272,123 (296)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A 3D dynamic window approach with receding horizon optimization for real-time UAV path planning

Complex & Intelligent Systems
Efficient and reliable path planning in complex three-dimensional (3D) environments remains a critical challenge for unmanned aerial vehicles (UAVs). Although the dynamic window approach (DWA) has demonstrated effectiveness in local planning, it suffers ...
Lingfeng Hu, Jianwei Ma, Shaofei Zang
doaj   +1 more source

Dynamic Window Approach Using GOA Search Algorithm for Collision Avoidance Based on Obstacle Trajectory Prediction

IEEE Access
Mobile robots not only need to navigate autonomously in complex environments, but also need to avoid collisions with dynamic obstacles, especially pedestrians. This paper realizes dynamic obstacles detection and state estimation algorithm with LiDAR data,
Yuan Liu, Lingyu Zhang, Jiasheng Liu, YingYing She, Birui Zhang, Feiyan Min   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Path-Planning Strategy: Adaptive Ant Colony Optimization Combined with an Enhanced Dynamic Window Approach

Electronics
Aiming to resolve the problems of slow convergence speed and inability to plan in real time when ant colony optimization (ACO) performs global path planning, we propose a path-planning method that improves adaptive ant colony optimization (IAACO) with ...
Dongri Shan, Shuaishuai Zhang, Xiaofang Wang, Peng Zhang   +3 more
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Safe Maritime Path Planning Fusion Algorithm for USVs Based on Reinforcement Learning A* and LSTM-Enhanced DWA

Sensors
In complex maritime environments, the safety of path planning for Unmanned Surface Vehicles (USVs) remains a significant challenge. Existing methods for handling dynamic obstacles often suffer from inadequate predictability and generate non-smooth ...
Zhenxing Zhang, Qiujie Wang, Xiaohui Wang, Mingkun Feng   +3 more
doaj   +1 more source

An Improved SOM-Based Method for Multi-Robot Task Assignment and Cooperative Search in Unknown Dynamic Environments

Energies, 2020
The methods of task assignment and path planning have been reported by many researchers, but they are mainly focused on environments with prior information.
Hongwei Tang, Anping Lin, Wei Sun, Shuqi Shi   +3 more
doaj   +1 more source

Optimal path planning using bidirectional rapidly-exploring random tree star-dynamic window approach (BRRT*-DWA) with adaptive Monte Carlo localization (AMCL) for mobile robot

Engineering Research Express
Path planning is an important task for mobileF service robots. Most of the available path-planning algorithms are applicable only in static environments. Achieving path planning becomes a difficult task in an unknown, dynamic environment.
Wubshet Ayalew, Muluken Menebo, Chala Merga, Lebsework Negash   +3 more
semanticscholar   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source