International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang +9 more
wiley +1 more source
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
, 2018 Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core +1 more source
Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. [PDF]
, 2015 Disrupting particular mitochondrial fission and fusion proteins leads to the death of specific neuronal populations; however, the normal functions of mitochondrial fission in neurons are poorly understood, especially in vivo, which limits the ...
Berthet, A +12 more
core +3 more sources
Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
Microorganisms, 2019 Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection.
Matthew R. Pennington +7 more
doaj +1 more source
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily [PDF]
, 2017 Mutations in LRRK2 cause autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative protein-protein interaction domains.
Bandopadhyay, Rina +11 more
core
Mechanochemical action of the dynamin protein
, 2008 Dynamin is a ubiquitous GTPase that tubulates lipid bilayers and is implicated in many membrane severing processes in eukaryotic cells. Setting the grounds for a better understanding of this biological function, we develop a generalized hydrodynamics ...
A. E. H. Love +21 more
core +1 more source
Overexpressing temperature-sensitive dynamin decelerates phototransduction and bundles microtubules in drosophila photoreceptors [PDF]
, 2009 shibire(ts1), a temperature-sensitive mutation of the Drosophila gene encoding a Dynamin orthologue, blocks vesicle endocytosis and thus synaptic transmission, at elevated, or restrictive temperatures.
Gonzalez-Bellido, P.T. +4 more
core +1 more source
Ciliate Biology: Dynamin Goes Nuclear [PDF]
Current Biology, 2008 Dynamin and dynamin-related proteins (DRPs) mediate an array of membrane fission processes. A Tetrahymena DRP has adopted a new role, assisting in nuclear differentiation, a finding that further highlights these proteins - and this ciliate - as biological innovators.
openaire +2 more sources
SH3 Domains Differentially Stimulate Distinct Dynamin I Assembly Modes and G Domain Activity.
PLoS ONE, 2015 Dynamin I is a highly regulated GTPase enzyme enriched in nerve terminals which mediates vesicle fission during synaptic vesicle endocytosis. One regulatory mechanism involves its interactions with proteins containing Src homology 3 (SH3) domains.
Sai Krishnan +2 more
doaj +1 more source
A Dynamin Mutant Defines a Superconstricted Prefission State
Cell Reports, 2014 Dynamin is a 100 kDa GTPase that organizes into helical assemblies at the base of nascent clathrin-coated vesicles. Formation of these oligomers stimulates the intrinsic GTPase activity of dynamin, which is necessary for efficient membrane fission during
Anna C. Sundborger +5 more
doaj +1 more source