Results 1 to 10 of about 43,287 (283)
The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor
eLife, 2022 Dynein harnesses ATP hydrolysis to move cargo on microtubules in multiple biological contexts. Dynein meets a unique challenge in meiosis by moving chromosomes tethered to the nuclear envelope to facilitate homolog pairing essential for gametogenesis ...
Ritvija Agrawal +7 more
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Cryo-EM captures early intermediate steps in dynein activation by LIS1 [PDF]
Nature CommunicationsCytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen +4 more
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Cargo-Mediated Activation of Cytoplasmic Dynein in vivo
Frontiers in Cell and Developmental Biology, 2020 Cytoplasmic dynein-1 is a minus-end-directed microtubule motor that transports a variety of cargoes including early endosomes, late endosomes and other organelles.
Xin Xiang, Rongde Qiu
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Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction
eLife, 2019 Cytoplasmic dynein plays critical roles within the developing and mature nervous systems, including effecting nuclear migration, and retrograde transport of various cargos.
Matthew G Marzo +5 more
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Nature Communications, 2018 A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes.
In-Gyun Lee +5 more
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TCTEX1D2 is essential for sperm flagellum formation in mice [PDF]
Scientific ReportsFlagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella.
Ryua Harima +2 more
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Nature Communications, 2023 Mitochondrial transport along microtubules is mediated by Miro1 and TRAK adaptors that recruit kinesin-1 and dynein-dynactin. To understand how these opposing motors are regulated during mitochondrial transport, we reconstitute the bidirectional ...
J. Canty +4 more
semanticscholar +1 more source
eLife, 2022 Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined.
Xiaoqin Fu +7 more
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Structures of human dynein in complex with the lissencephaly 1 protein, LIS1
eLife, 2023 The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer +3 more
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Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
Nature Communications, 2021 Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell
Adam R. Fenton, T. Jongens, E. Holzbaur
semanticscholar +1 more source