Results 111 to 120 of about 43,287 (283)
PLoS ONE, 2011 Microtubule-dependent movement is crucial for the spatial organization of endosomes in most eukaryotes, but as yet there has been no systematic analysis of how a particular microtubule motor contributes to early endosome dynamics.
Neftali Flores-Rodriguez +5 more
doaj +1 more source
Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly
Journal of Cell Biology, 2017 The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle microtubule capture and to control spindle checkpoint signaling.
José B. Gama +11 more
semanticscholar +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Non‐small cell lung cancer (NSCLC) is a common and fatal malignancy. This study aimed to elucidate the mechanism of Kruppel‐like factor (KLF1) in NSCLC progression. Clinical samples were collected, after which the expression levels of KLF1, LINC02159, and dynein cytoplasmic 1 heavy chain 1 (DYNC1H1) in tissues and cells were initially detected,
Han Yang
wiley +1 more source
Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains
eLife, 2013 Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs within MT networks such as mitotic spindles. How dynein performs such non-
Marvin E Tanenbaum +2 more
doaj +1 more source
Traffic : the International Journal of Intracellular Transport, 2019 Bidirectional cargo transport along microtubules is carried out by opposing teams of kinesin and dynein motors. Despite considerable study, the factors that determine whether these competing teams achieve net anterograde or retrograde transport in cells ...
Kazuka G. Ohashi +5 more
semanticscholar +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, EarlyView.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Biology Open, 2013 Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin +6 more
doaj +1 more source
Dynein Harnesses Active Fluctuations of Microtubules for Faster Movement
Nature Physics, 2019 The cytoskeleton forms a dynamic network that generates fluctuations larger than thermal agitation of the cytoplasm 1 . Here, we tested whether dynein, a minus-end-directed microtubule (MT) motor 2 , can harness energy from these fluctuations using ...
Yasin Ezber +3 more
semanticscholar +1 more source
Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire
PROTEOMICS, EarlyView.ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley +1 more source
Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3
bioRxiv, 2016 Metazoan cytoplasmic dynein moves processively along microtubules with the aid of dynactin and an adaptor protein that joins dynein and dynactin into a stable ternary complex.
C. M. Schroeder, R. Vale
semanticscholar +1 more source