Results 121 to 130 of about 43,287 (283)
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
The mammalian dynein/dynactin complex is a strong opponent to kinesin in a tug-of-war competition
Nature Cell Biology, 2016 Kinesin and dynein motors transport intracellular cargos bidirectionally by pulling them in opposite directions along microtubules, through a process frequently described as a ‘tug of war’. While kinesin produces 6 pN of force, mammalian dynein was found
V. Belyy +5 more
semanticscholar +1 more source
Molecular Motors: Dynein's Gearbox [PDF]
Current Biology, 2004 A new optical trapping study shows that the stepsize of cytoplasmic dynein varies according to the applied force, suggesting that this motor can change gear. Complementary biochemical kinetic work on yeast dynein mutants hints at the allosteric mechanisms involved.
openaire +3 more sources
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
From Fluctuations to Function: Unveiling the Role of Stochasticity in Life‐Like Systems
ChemSystemsChem, EarlyView.In this short review, we put forward the idea that randomly fluctuating, or stochastic, molecular events can and do play a role in the emergence of complex biological phenomena at longer length scales. There is a growing body of evidence of this occurring in natural systems, and we survey the computational and experimental attempts of researchers to ...
Aleksa Lakic, Alexander F. Mason
wiley +1 more source
bioRxiv, 2018 Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi +3 more
semanticscholar +1 more source
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source
ZMYND10 functions in a chaperone relay during axonemal dynein assembly
eLife, 2018 Molecular chaperones promote the folding and macromolecular assembly of a diverse set of ‘client’ proteins. How ubiquitous chaperone machineries direct their activities towards specific sets of substrates is unclear.
Girish R Mali +15 more
doaj +1 more source
A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1)
Molecular Biology of the Cell, 2018 FAP44 and FAP43/FAP244 form a complex that tethers the Inner dynein subspecies f to the microtubule in Chlamydomonas flagella. The tether complex regulates flagellar motility by restraining conformational change in the dynein motor.
T. Kubo +4 more
semanticscholar +1 more source
Identification of dynein as the outer arms of sea urchin sperm axonemes. [PDF]
, 1977 K Ogawa, Toshiko Mohri, Hideo Mohri
openalex +1 more source