Results 151 to 160 of about 43,287 (283)

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells

open access: yesBioEssays, Volume 47, Issue 11, November 2025.
Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin   +15 more
wiley   +1 more source

Proteome‐Wide 4‐Hydroxy‐2‐Nonenal Signature of Oxidative Stress in the Marine Invasive Tunicate Botryllus schlosseri

open access: yesPROTEOMICS, Volume 25, Issue 19, Page 12-25, October 2025.
ABSTRACT The ascidian Boytryllus schlosseri is a marine chordate that thrives under conditions of anthropogenic climate change. The B. schlosseri expressed proteome contains unusually high levels of proteins adducted with 4‐hydroxy‐2‐nonenal (HNE). HNE represents a prominent posttranslational modification resulting from oxidative stress.
Dietmar Kültz   +6 more
wiley   +1 more source

EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice

open access: yesAndrology, Volume 13, Issue 7, Page 1901-1912, October 2025.
Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang   +7 more
wiley   +1 more source

Arrangement of inner dynein arms in wild-type and mutant flagella of Chlamydomonas. [PDF]

open access: bronze, 1992
David N. Mastronarde   +4 more
openalex   +1 more source

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